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The role of hepatic and renal functions in the development of retinopathy of prematurity: Is proteinuria a new risk factor?

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Abstract

Purpose

To investigate the association of hepatic and renal parameters with the development of retinopathy of prematurity (ROP) in premature infants with a gestational age ≤ 32 weeks.

Methods

Medical records of 240 preterm infants were reviewed retrospectively, 85 of them were grouped as type 1, type 2 ROP, and control group. The 4th week hepatic and renal function test results of the groups, on the day of their first ROP examinations, were compared for the risk of development of ROP and the development of type 1 ROP.

Results

In this study, 12, 35, and 38 infants were enrolled in the type 1, type 2 ROP, and control group, respectively. The average gestational age and birth weight were higher; however, the duration of oxygen treatment was lower in the control group (p < 0.001). The blood glucose level was significantly higher in the type 1 ROP group than in the other groups (p = 0.023). The mean of total serum bilirubin of the type 1 ROP group was significantly lower than those of the type 2 ROP and control group (p = 0.032). Proteinuria was present in 85.7% of preterms with treatment-requiring ROP and proteinuria increased the risk of ROP by 3.9 times (OR with 95% CI 3.9 (1.19–12.75), p = 0.042).

Conclusion

We found significantly higher blood glucose and lower total bilirubin level in the type 1 ROP group. Moreover, our findings suggest that proteinuria may not be only a comorbidity factor but also related to a higher frequency of ROP and type 1 ROP in preterm infants.

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Acknowledgements

This study was presented as a free paper at the 51st National Congress of the Turkish Ophthalmological Association.

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Authors and Affiliations

  1. Department of Ophthalmology, Bakircay University Cigli Training and Research Hospital, Izmir, Turkey

    Sayime Aydin Eroglu

  2. Department of Ophthalmology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey

    Ayse Ipek Akyuz Unsal & Duygu Guler

  3. Department of Ophthalmology, Aydin State Hospital, Aydin, Turkey

    Ozge Key Abdullayev

  4. Department of Neonatology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey

    Munevver Kaynak Turkmen

  5. Private Clinic, Aydin, Turkey

    Seyhan B. Özkan

  6. Department of Medical Pharmacology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey

    Buket Demirci

  7. Department of Biostatistics, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey

    Imran Kurt Omurlu

Authors
  1. Sayime Aydin Eroglu
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  2. Ayse Ipek Akyuz Unsal
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Contributions

Study design was made by Ayse Ipek Akyuz Unsal and Buket Demirci, Material preparation and data collection were made by Ozge Key, Duygu Guler, Imran Kurt Omurlu did a statistical analysis of the study and prepared the figure, Seyhan B. Özkan, Munevver Kaynak Turkmen, Ayse Ipek Akyuz Unsal and Buket Demirci, Sayime Aydin Eroglu were supervisor of the study, Sayime Aydin Eroglu and Ayse Ipek Akyuz Unsal wrote the main manuscript and prepared the tables, All authors reviewed the manuscript.

Corresponding author

Correspondence to Sayime Aydin Eroglu.

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Author declares no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical approval

Approved by the following research ethics committee: Aydin Adnan Menderes University Ethical Committee and Review Board (code and decision number: 2016/901; 26.05.2016/13).

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Eroglu, S.A., Unsal, A.I.A., Abdullayev, O.K. et al. The role of hepatic and renal functions in the development of retinopathy of prematurity: Is proteinuria a new risk factor?. Int Ophthalmol 43, 483–490 (2023). https://doi.org/10.1007/s10792-022-02445-9

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  • DOI: https://doi.org/10.1007/s10792-022-02445-9

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