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Secondary glaucoma caused by a special type of persistent fetal vasculature

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Abstract

Purpose

To investigate the clinical features and surgical outcomes in infants with glaucoma secondary to a special anterior-anterior type of persistent fetal vasculature (AAPFV).

Methods

This study retrospectively reviewed the medical records of infants who underwent of the synechialysis, pupilloplasty, with or without lensectomy and limbal vitrectomy due to AAPFV and with at least 6 months of postoperative follow-up.

Results

Eleven patients were included. The median age at surgery was 4.0 months (interquartile range: 7 months). The mean follow-up was 21.0 ± 11.3 months. All patients achieved a normal anterior chamber, improved pupillary configuration, and normal intraocular pressure (IOP), except one that developed phthisis bulbi at the last visit. A total of 81.8% (9/11) eyes exhibited improved corneal transparency. Histopathologic findings of four pupillary membranous specimens under light microscopy showed similar components compared with PFV. Two eyes developed postoperative complications, including retinal detachment and hyphema, requiring additional surgeries. Postoperative visual acuity changed from no light perception to light perception in 6/9 patients.

Conclusions

AAPFV is a special type of PFV with a potential for secondary glaucoma. Surgery treatment may offer better vision with improved cosmetic outcomes and a better controlled IOP.

Trial registration

The study was approved by the local institutional review board (IRB) (Approval No. XHEC-D-2021–043, Ethical Committee of Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China).

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Availability of data and materials

All data generated or analyzed during this study are included in this published article.

Abbreviations

AAPFV:

Anterior-anterior type of persistent fetal vasculature

APFV:

Anterior persistent fetal vasculature

IOP:

Intraocular pressure

OVD:

Ophthalmic viscosurgical device

FFA:

Fundus fluorescein angiography

SD:

Standard deviation

LP:

Light perception

NLP:

No light perception,

AL:

Axial length

RD:

Retinal detachment

AC:

Anterior chamber

IVR:

Intravitreous Lucentis

PPFV:

Posterior persistent fetal vasculature

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Funding

The design of the study was funded by the National Natural Science Foundation of China under Grant 81770964 to Peiquan Zhao and Shanghai Sailing Program under Grant 20YF1429700 to Jie Peng.

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Authors and Affiliations

  1. Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road, No. 1665, Shanghai, 200092, China

    Jianing Ren, Jiao Lyu, Hongfei Ye, Jingjing Liu, Jie Peng & Peiquan Zhao

Authors
  1. Jianing Ren
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  2. Jiao Lyu
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  3. Hongfei Ye
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  4. Jingjing Liu
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  5. Jie Peng
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  6. Peiquan Zhao
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Contributions

Dr PZ and Dr JP had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors contributed to study concept and design. JR contributed to acquisition, analysis, or interpretation of data. JR contributed to drafting of the manuscript. HY, JL contributed to critical revision of the manuscript for important intellectual content. JL contributed to administrative, technical, or material support. JP, PZ contributed to study supervision. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Jie Peng or Peiquan Zhao.

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Conflict of interest

The authors declare that they have no competing interests.

Ethics approval and consent to participate

The research followed the tenets of the Declaration of Helsinki and the study was approved by the local institutional review board (IRB) (Approval No. XHEC-D-2021–043, Ethical Committee of Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China).

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Each patient signed an informed consent.

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Ren, J., Lyu, J., Ye, H. et al. Secondary glaucoma caused by a special type of persistent fetal vasculature. Int Ophthalmol 42, 2871–2879 (2022). https://doi.org/10.1007/s10792-022-02277-7

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  • DOI: https://doi.org/10.1007/s10792-022-02277-7

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