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Intravitreal dexamethasone implant for noninfectious uveitis in Chinese patients

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Abstract

Purpose

To evaluate the effectiveness and safety of the dexamethasone intravitreal implant (DEX-I) in Non-Infectious Uveitis (NIU) in Chinese patients.

Methods

Ninety-one eyes of 77 patients (56 men, 21 women) receiving 130 implant injections for NIU were included. Treatment indication, uveitis diagnosis, best-corrected visual acuity (BCVA), central retinal thickness (CRT), vitreous haze score, intraocular pressure, phakic status, number of injections, time to reinjection, and systemic treatments were collected at baseline, 1 week, 1 month, 3 and 6 months after treatment.

Results

All patients were followed for at least 12 weeks and had a mean follow-up period of 5.1 months (range, 3–14 months) after the first implant. The main treatment indications were macular edema (ME), retinal vasculitis, retinal vasculitis with ME. Sixty-one eyes (67.03%) received only one injection, while 31 eyes (32.97%) received two or more. In eyes that received 2 injections, the mean time to the second injection was 3.83 months and in those that received 3 injections, the mean time to the third injection was 7.5 months. BCVA and CRT significantly improved at 1 week, 1 month, 3 months, and 6 months after treatment. When compared to baseline, the mean prednisone (or equivalent) dosage significantly decreased at 3- and 6-month follow-up evaluations after DEX implantation.14.29% of eyes developed a transient increase in intraocular pressure, and a cataract was removed from 1 phakic eye.

Conclusions

DEX implants, either alone or in combination with common adjunctive NIU treatments, is safe and effective in the treatment of NIU in Chinese patients.

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References

  1. Gritz DC, Wong IG (2004) Incidence and prevalence of uveitis in Northern California; the Northern California epidemiology of uveitis study. Ophthalmology 111(3):491–500. https://doi.org/10.1016/j.ophtha.2003.06.014 (discussion 500)

    Article  PubMed  Google Scholar 

  2. Suhler EB, Lloyd MJ, Choi D, Rosenbaum JT, Austin DF (2008) Incidence and prevalence of uveitis in veterans affairs medical centers of the Pacific Northwest. Am J Ophthalmol 146(6):890-896 e898. https://doi.org/10.1016/j.ajo.2008.09.014

    Article  PubMed  Google Scholar 

  3. Acharya NR, Tham VM, Esterberg E, Borkar DS, Parker JV, Vinoya AC, Uchida A (2013) Incidence and prevalence of uveitis: results from the pacific ocular inflammation study. JAMA Ophthalmol 131(11):1405–1412. https://doi.org/10.1001/jamaophthalmol.2013.4237

    Article  PubMed  Google Scholar 

  4. Miserocchi E, Fogliato G, Modorati G, Bandello F (2013) Review on the worldwide epidemiology of uveitis. Eur J Ophthalmol 23(5):705–717. https://doi.org/10.5301/ejo.5000278

    Article  PubMed  Google Scholar 

  5. Durrani OM, Tehrani NN, Marr JE, Moradi P, Stavrou P, Murray PI (2004) Degree, duration, and causes of visual loss in uveitis. Br J Ophthalmol 88(9):1159–1162. https://doi.org/10.1136/bjo.2003.037226

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Thorne JE, Skup M, Tundia N, Macaulay D, Revol C, Chao J, Joshi A, Dick AD (2016) Direct and indirect resource use, healthcare costs and work force absence in patients with non-infectious intermediate, posterior or panuveitis. Acta Ophthalmol 94(5):e331-339. https://doi.org/10.1111/aos.12987

    Article  PubMed  PubMed Central  Google Scholar 

  7. Wakefield D, Chang JH (2005) Epidemiology of uveitis. Int Ophthalmol Clin 45(2):1–13. https://doi.org/10.1097/01.iio.0000155938.83083.94

    Article  PubMed  Google Scholar 

  8. Deschenes J, Murray PI, Rao NA, Nussenblatt RB, International Uveitis Study G (2008) International uveitis study group (IUSG): clinical classification of uveitis. Ocul Immunol Inflamm 16(1):1–2. https://doi.org/10.1080/09273940801899822

    Article  PubMed  Google Scholar 

  9. Tomkins-Netzer O, Taylor SR, Lightman S (2012) Corticosteroid-sparing agents: new treatment options. Dev Ophthalmol 51:47–56. https://doi.org/10.1159/000336186

    Article  CAS  PubMed  Google Scholar 

  10. Sella R, Oray M, Friling R, Umar L, Tugal-Tutkun I, Kramer M (2015) Dexamethasone intravitreal implant (Ozurdex(R)) for pediatric uveitis. Graefes Arch Clin Exp Ophthalmol 253(10):1777–1782. https://doi.org/10.1007/s00417-015-3124-x

    Article  CAS  PubMed  Google Scholar 

  11. Lightman S, Belfort R Jr, Naik RK, Lowder C, Foster CS, Rentz AM, Cui H, Whitcup SM, Kowalski JW, Revicki DA (2013) Vision-related functioning outcomes of dexamethasone intravitreal implant in noninfectious intermediate or posterior uveitis. Invest Ophthalmol Vis Sci 54(7):4864–4870. https://doi.org/10.1167/iovs.12-10981

    Article  CAS  PubMed  Google Scholar 

  12. Lowder C, Belfort R Jr, Lightman S, Foster CS, Robinson MR, Schiffman RM, Li XY, Cui H, Whitcup SM, Ozurdex HSG (2011) Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. Arch Ophthalmol 129(5):545–553. https://doi.org/10.1001/archophthalmol.2010.339

    Article  PubMed  Google Scholar 

  13. Moisseiev E, Goldstein M, Waisbourd M, Barak A, Loewenstein A (2013) Long-term evaluation of patients treated with dexamethasone intravitreal implant for macular edema due to retinal vein occlusion. Eye (Lond) 27(1):65–71. https://doi.org/10.1038/eye.2012.226

    Article  CAS  Google Scholar 

  14. Fabiani C, Vitale A, Lopalco G, Iannone F, Frediani B, Cantarini L (2016) Different roles of TNF inhibitors in acute anterior uveitis associated with ankylosing spondylitis: state of the art. Clin Rheumatol 35(11):2631–2638. https://doi.org/10.1007/s10067-016-3426-3

    Article  PubMed  Google Scholar 

  15. Fardeau C, Champion E, Massamba N, LeHoang P (2016) Uveitic macular edema. Eye (Lond) 30(10):1277–1292. https://doi.org/10.1038/eye.2016.115

    Article  CAS  Google Scholar 

  16. Fabiani C, Alio JL (2015) Local (topical and intraocular) therapy for ocular Adamantiades-Behcet’s disease. Curr Opin Ophthalmol 26(6):546–552. https://doi.org/10.1097/ICU.0000000000000210

    Article  PubMed  Google Scholar 

  17. Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature Working G (2005) Standardization of uveitis nomenclature for reporting clinical data Results of the first international workshop. Am J Ophthalmol 140(3):509–516. https://doi.org/10.1016/j.ajo.2005.03.057

    Article  PubMed  Google Scholar 

  18. Nobre-Cardoso J, Champion E, Darugar A, Fel A, Lehoang P, Bodaghi B (2017) Treatment of non-infectious uveitic macular edema with the intravitreal dexamethasone implant. Ocul Immunol Inflamm 25(4):447–454. https://doi.org/10.3109/09273948.2015.1132738

    Article  CAS  PubMed  Google Scholar 

  19. Habot-Wilner Z, Sorkin N, Goldenberg D, Goldstein M (2015) Bilateral effect of unilateral dexamethasone intravitreal implant in a case of noninfectious uveitic macular edema and vitritis. Retin Cases Brief Rep 9(2):151–153. https://doi.org/10.1097/ICB.0000000000000122

    Article  PubMed  Google Scholar 

  20. Sharma A, Sheth J, Madhusudan RJ, Sundaramoorthy SK (2013) Effect of intravitreal dexamethasone implant on the contralateral eye: a case report. Retin Cases Brief Rep 7(3):217–219. https://doi.org/10.1097/ICB.0b013e31828993a1

    Article  PubMed  Google Scholar 

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Funding

This study was funded by the National Natural Science Foundation of China (81300752), the Jilin Province Science and Technology Development Plan Project (20200201333JC) and the Jilin Province Health Special Project (2020SCZT058).

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Authors and Affiliations

  1. Ophthalmologic Center of the Second Hospital, Jilin University, Ziqiang Street 218, Changchun, 130000, People’s Republic of China

    Shun Zeng, Li Yang, Feng Bai, Tao Liu & Xiaoli Liu

Authors
  1. Shun Zeng
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  2. Li Yang
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  3. Feng Bai
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  4. Tao Liu
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  5. Xiaoli Liu
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Corresponding author

Correspondence to Xiaoli Liu.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the Second Hospital of Jilin University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Zeng, S., Yang, L., Bai, F. et al. Intravitreal dexamethasone implant for noninfectious uveitis in Chinese patients. Int Ophthalmol 42, 2063–2069 (2022). https://doi.org/10.1007/s10792-021-02204-2

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  • DOI: https://doi.org/10.1007/s10792-021-02204-2

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