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Spectrum of AS-OCT features of ocular surface tumors and correlation of clinico-tomographic features with histopathology: a study of 70 lesions

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Abstract

Purpose

To assess the correlation between clinical and anterior segment optical coherence tomographic (AS-OCT) details and histopathological changes in various ocular surface lesions.

Methods

Prospective case series of 70 lesions in 65 patients.

Results

AS-OCT revealed epithelial changes in OSSN (n = 19; 44%), squamous papilloma (n = 3; 60%), nevus (n = 1; 33%), epithelial hyperplasia (n = 1; 33%), granular dystrophy (n = 1; 100%) and granulation tissue (n = 1; 100%); subepithelial changes in chronic inflammation (n = 4, 100%), lymphoma (n = 3; 100%) and arteriovenous malformation (n = 1; 100%); combined epithelial and subepithelial changes in OSSN (n = 24; 56%), squamous papilloma (n = 2; 40%), PEH (n = 3; 100%), nevus (n = 2; 67%), epithelial hyperplasia (n = 2; 67%), solar elastosis (n = 1; 100%), lobular capillary hemangioma (n = 1; 100%) and sebaceous carcinoma (n = 1; 100%). Epithelial involvement on AS-OCT paralleled the histopathological findings in 98% (n = 69) and subepithelial involvement in 83% (n = 58). The correlation of clinico-tomographic diagnosis with histopathology diagnosis was seen in 77% (n = 54) lesions. Sensitivity and specificity of AS-OCT as a diagnostic tool for detection of epithelial involvement were 100% and 92% and for subepithelial involvement was 98% and 100%, respectively.

Conclusion

The correlation between AS-OCT and histopathology features determining epithelial and subepithelial involvement is excellent. It is a useful adjunctive tool for the diagnosis of ocular surface lesions.

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Availability of data and material

Data are available with the authors.

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Funding

Support provided by The Operation Eyesight Universal Institute for Eye Cancer (SK) and Hyderabad Eye Research Foundation (SK), Hyderabad, India. The funders had no role in the preparation, review or approval of the manuscript.

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Authors and Affiliations

  1. Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 500034, India

    Vijitha S. Vempuluru, Anushri Godbole & Swathi Kaliki

  2. Ophthalmic Pathology Laboratory, LV Prasad Eye Institute, Hyderabad, India

    Saumya Jakati & Dilip K. Mishra

  3. Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India

    Ashik Mohamed

Authors
  1. Vijitha S. Vempuluru
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  2. Saumya Jakati
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  3. Anushri Godbole
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  4. Dilip K. Mishra
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  5. Ashik Mohamed
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  6. Swathi Kaliki
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Contributions

VSV was responsible for data collection, interpretation of images and drafting the manuscript. SJ was responsible for histopathological correlation and drafting of the manuscript. AG was responsible for data acquisition and data analysis. DKM was responsible for histopathological assessment, correlation and editing the manuscript. AM was responsible to data analysis and critical review of the manuscript. SK was responsible for the concept and formulation of the work, assessment of clinical, tomographic and histopathological correlation and editing of the manuscript.

Corresponding author

Correspondence to Swathi Kaliki.

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No conflicting relationships exist for any author.

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This study has been approved by the Institute Ethics Committee.

Ethical standards

This work involved demographic and clinical information of human participants. All procedures performed were in accordance with the ethical standards of the institutional ethics committee and adhered to the Declaration of Helsinki, 1964 and its later amendments or comparable ethical standards.

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Consent to participate was obtained from the patients.

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Consent for publication was obtained from the patients.

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Informed consent has been obtained from all study participants.

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Vempuluru, V.S., Jakati, S., Godbole, A. et al. Spectrum of AS-OCT features of ocular surface tumors and correlation of clinico-tomographic features with histopathology: a study of 70 lesions. Int Ophthalmol 41, 3571–3586 (2021). https://doi.org/10.1007/s10792-021-01939-2

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