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Macular sequelae in vasoproliferative tumors: results of surgical approach

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Abstract

Purpose

The purpose of this study is to report the clinical manifestations and treatment outcomes in three patients diagnosed with vasoproliferative tumors (VPTs).

Methods

A retrospective, single-center case series was conducted, and retinal findings from three cases were documented by clinical examination and multimodal imaging.

Results

Three patients presented with an elevated, yellow-white retinal lesion located at the peripheral retina and extensive retinal exudation. All three patients were closely monitored, and tumor-associated features included lipid exudates, cystoid macular edema (CMO), pre-retinal fibrosis and epi-retinal membrane (ERM). Clinical management relied on observation, cryotherapy, laser photocoagulation, intravitreal steroids and anti-vascular endothelial growth factor (anti-VEGF) treatment. Despite different clinical courses, two patients underwent vitreo-retinal surgery to address VPT-related complications of macular hole and vitreo-macular traction, whereas a patient underwent phacoemulsification to treat steroid-induced cataract.

Conclusion

VPTs are uncommon benign vascular tumors and usually located at the infero-temporal peripheral retina. Close observation and early diagnosis of VPTs are of great importance in preventing vision-threatening complications and ensuring the best final visual outcome. The optimal treatment has yet to be defined due to lack of multi-center clinical studies. Despite the availability of less invasive therapeutic interventions, however, our case series show that pars plana vitrectomy is sometimes the most appropriate choice to restore visual acuity.

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All data and materials support our published claims and comply with field standards.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Ophthalmology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloníki, Greece

    Asterios Diafas, Ioannis Kassos, Maria Samouilidou, Anna Dastiridou & Nikolaos Ziakas

  2. Department of Ophthalmology, University of Thessaly, Larissa, Greece

    Victoria Toumanidou & Sofia Androudi

Authors
  1. Asterios Diafas
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  2. Victoria Toumanidou
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  3. Ioannis Kassos
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  4. Maria Samouilidou
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  5. Anna Dastiridou
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  6. Nikolaos Ziakas
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  7. Sofia Androudi
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Contributions

All authors contributed to the study conception and design. Patients’ examination, diagnosis and material preparation were performed by Dr Victoria Toumanidou, Dr Maria Samouilidou and Dr Ioannis Kassos. All patients were operated by Dr Sofia Androudi. Dr Anna Dastiridou contributed to data collection and presentation. The original draft of the manuscript was written by Dr Asterios Diafas, and all authors commented on final version of the manuscript. Dr Sofia Androudi and Dr Nikolaos Ziakas supervised research activity planning and execution. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sofia Androudi.

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The author declare that they do not have any conflict of interest.

Ethical approval

The study followed the tenets of the Declaration of Helsinki and was approved by the local biomedical ethics committee.

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A written informed consent was obtained from all participants after detailed explanation of the research.

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We obtained informed consent to publish the data and pictures from the patients presented in this article.

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Diafas, A., Toumanidou, V., Kassos, I. et al. Macular sequelae in vasoproliferative tumors: results of surgical approach. Int Ophthalmol 41, 3515–3522 (2021). https://doi.org/10.1007/s10792-021-01918-7

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  • DOI: https://doi.org/10.1007/s10792-021-01918-7

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