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Ocular surface disease in psoriatic patients in a developing country

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Abstract

Purpose

To evaluate ocular surface changes among patients with psoriasis in Malaysia, a developing country in Southeast Asia.

Methods

An interdisciplinary case–control study (60 psoriasis patients and 40 control subjects) to look at the differences in ocular surface manifestations between patients with psoriasis and a group of age-, gender- and ethnicity-matched healthy controls.

Results

One hundred and twenty eyes of 60 patients with psoriasis and 80 eyes of 40 healthy controls without psoriasis were included in the study. Mild-to-moderate psoriasis was found in 42 patients (70%), while 18 patients (30%) had severe psoriasis. Psoriatic arthritis was found in 19 patients (32%). Of the 60 psoriatic patients, the prevalence of ocular involvement was 65% (39/60), in which 32% (19/60) had dry eyes, 27% (16/60) had lid margin abnormalities, 33% (20/60) had cataract, and one had history of anterior uveitis. Compared to controls, ocular surface of psoriatic patients showed more eyelid margin abnormalities, higher meibomian gland loss and lower tear film break-up time. The estimated odds ratio for dry eyes in the psoriasis group was 2.2 (95% CI: 0.8–6.9).

Conclusion

Ocular surface disorders encompassing eyelid margin abnormalities, meibomian gland loss and tear dysfunction occur at an earlier and higher rate among psoriatic patients.

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Acknowledgements

We are grateful to Dr. Noor Ezailina Badarudin (PhD) and her team, Department of Optometry and Visual Science, International Islamic University Malaysia, Pahang, Malaysia, for providing the Malay language version of Ocular Surface Disease Index (OSDI).

Funding

This work was supported by University of Malaya Research Fund Assistance (BKP; BK035-2018) from University of Malaya to Dr Sujaya Singh.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, University of Malaya Eye Research Centre, University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia

    Yihui Goh, Tajunisah Iqbal, Tsung Fei Khang & Sujaya Singh

  2. Division of Dermatology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Zhenli Kwan & Winn Hui Han

  3. Division of Rheumatology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Fariz Yahya

  4. Institute of Mathematical Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia

    Tsung Fei Khang

Authors
  1. Yihui Goh
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  2. Zhenli Kwan
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  3. Winn Hui Han
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  4. Tajunisah Iqbal
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  5. Fariz Yahya
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  6. Tsung Fei Khang
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  7. Sujaya Singh
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Yihui Goh, Winn Hui Han, Zhenli Kwan, Tsung Fei Khang, and Sujaya Singh. The first draft of the manuscript was written by Yihui Goh, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Sujaya Singh.

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Goh, Y., Kwan, Z., Han, W.H. et al. Ocular surface disease in psoriatic patients in a developing country. Int Ophthalmol 41, 2139–2147 (2021). https://doi.org/10.1007/s10792-021-01771-8

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  • DOI: https://doi.org/10.1007/s10792-021-01771-8

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