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Evaluating the safety and efficacy of compression sutures with intracameral perfluoropropane (C3F8) in the management of acute corneal hydrops

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Abstract

Background

To evaluate the safety and efficacy of using corneal compression sutures with intracameral perfluoropropane (C3F8) in patients presenting with acute corneal hydrops in ectatic disorders.

Methods

A retrospective analysis was done for 43 eyes of patients of acute corneal hydrops, managed using a combination of intracameral 14% C3F8 and full-thickness compression sutures. Time for resolution of edema, corneal thickness (CT) change on anterior segment ocular coherence tomography (ASOCT), and visual outcomes were assessed.

Results

Corneal edema resolved with a mean duration of 14.8 ± 3.5 days (range 10–21). The mean CT on ASOCT decreased from a mean of 1437 µm (689–2770 µm) preoperatively to 543 µm (434 –66 µm) on the complete resolution of corneal edema.

Conclusion

Our results suggest that full-thickness compression sutures and intracameral C3F8 injection can restore the imperviousness of posterior stroma. This technique appears to be a safe and effective technique for faster resolution of corneal edema post hydrops.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Code availability

Not applicable.

Abbreviations

C3F8:

Perfluoropropane

CT:

Corneal thickness

ASOCT:

Anterior segment ocular coherence tomography

KC:

Keratoconus

PMD:

Pellucid marginal disease

DALK:

Deep anterior lamellar keratoplasty

PK:

Penetrating keratoplasty

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Funding

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Authors and Affiliations

  1. Narayana Nethralaya Eye Hospital, Bangalore, India

    Vishal Vohra, Rohit Shetty, Edwin James, Gairik Kundu & Sharon D’Souza

  2. Department of Ophthalmology, Royal Victoria Infirmary, NE1 4LP, New Castle Upon Tyne, UK

    Vishal Vohra

Authors
  1. Vishal Vohra
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  2. Rohit Shetty
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  3. Edwin James
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  4. Gairik Kundu
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  5. Sharon D’Souza
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Contributions

VV was instrumental in data collection, analysis, and manuscript writing. RS designed the study and did substantive proofreading. SD formatted the manuscript and participated in content writing. EJ and GK helped in data collection and statistical analysis. All authors read and approved the manuscript before submission.

Corresponding author

Correspondence to Vishal Vohra.

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Ethics approval and consent to participate

Informed written consents were obtained from all participants before recruitment in this study and before undertaking the surgical procedure. Institutional Review Board approved the study.

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Consent to participate included the consent for publication of data in anonymized form for scientific purposes.

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Vohra, V., Shetty, R., James, E. et al. Evaluating the safety and efficacy of compression sutures with intracameral perfluoropropane (C3F8) in the management of acute corneal hydrops. Int Ophthalmol 41, 2027–2031 (2021). https://doi.org/10.1007/s10792-021-01758-5

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  • DOI: https://doi.org/10.1007/s10792-021-01758-5

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