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Corneal endothelial status in different grades of late spontaneous in-the-bag IOL dislocation

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Abstract

Purpose

 To evaluate corneal endothelial cell density (ECD) in the eyes with different grades of late spontaneous in-the-bag intraocular lens (IOL) dislocation.

Methods

 A prospective study included seventy-eight patients who applied for IOL dislocation. Overall 80 eyes were divided into four grades based on the in-the-bag IOL dislocation classification. All eyes underwent a complete ophthalmological examination. ECD was evaluated using in vivo corneal confocal microscopy.

Results

 Median corneal ECD was 1929 (1022–2958) cells/mm2 of all the patients. The lowest number of ECD was in grade 2 (grade 1 median ECD 1990.33 (1182–2425.33) cells/mm2, grade 2—1577.0 (1022–2958) cells/mm2, grade 3—2205.84 (1259–2807.67) cells/mm2 and grade 4—2072.17 (1045–2581.0) cells/mm2). A statistically significant difference was observed between the median of ECD of grade 2nd and 3rd (p = 0.023). By grouping cases into those with and without glaucoma, we found that corneal ECD was significantly lower in eyes with glaucoma compared with eyes without glaucoma in grades 3 and 4 (p < 0.05), while in other grades, the difference did not reach the significance level. We divided the corneal ECD of all eyes into two categories ≤ 1500 cells/mm2 and  > 1500 cells/mm2. Logistic regression demonstrated that the odds of having corneal ECD less than 1500 cells/mm2 increased by 3.5-fold if patients with IOL dislocation had been diagnosed with glaucoma previously.

Conclusion

 Late spontaneous in-the-bag IOL dislocation reduced corneal ECD. Previously diagnosed glaucoma was the most common comorbidity. This condition has a significant impact on corneal ECD for patients with IOL dislocation.

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*, ** Kruskal–Wallis test, p < 0.05

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*,**,*** Kruskal–Wallis test, p < 0.05

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*Kruskal–Wallis test, p < 0.05

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*, **Kruskal–Wallis test, p < 0.05

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Data availability

The data that support the findings of the present study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors would like to thank Irena Nedzelskiene (Lithuanian University of Health Sciences, Medical Academy, Department of Dental and Oral Pathology) for help in statistical analysis and Audrius Liutkus for help in preparing illustrations.

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The authors have no funding received for this work to disclose.

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  1. Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu st. 2, LT-50161, Kaunas, Lithuania

    Renata Vaiciuliene & Vytautas Jasinskas

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  1. Renata Vaiciuliene
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RV and JV were involved in the design and conduct of the study, in the collection, management, analysis, and interpretation of data, and in preparation, review and final approval of the manuscript.

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Correspondence to Renata Vaiciuliene.

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Vaiciuliene, R., Jasinskas, V. Corneal endothelial status in different grades of late spontaneous in-the-bag IOL dislocation. Int Ophthalmol 41, 1625–1634 (2021). https://doi.org/10.1007/s10792-021-01702-7

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