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Impact of sub-foveal choroidal thickness on clinical features and long-term clinical outcomes in polypoidal choroidal vasculopathy

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Abstract

Purpose

To study the clinical features and long-term clinical outcomes in polypoidal choroidal vasculopathy (PCV) in eyes with different sub-foveal choroidal thickness (SFCT).

Methods

In this retrospective, observational comparative study, treatment-naïve eyes diagnosed with PCV using the ‘EVEREST-2’ study criteria were included. The eyes were divided into three groups of thin, medium and thick choroids, based on the SFCT data of total study eyes. Demographic, clinical, imaging features and treatment outcomes between the 3 groups were compared.

Results

Sixty-three eyes in 63 patients were included. Right eye was involved in 39 (61%) cases and left eye in 24 (39%) cases. Mean age was 68.3 ± 6.82 years (range 54–85 years). Mean SFCT was 274 µm (median = 269 µm), and one standard deviation was 79.2 µm. Totally, 11, 43 and 9 eyes were included in the thin, medium and thick choroid groups, respectively. The mean SFCT was 161 ± 24.1 µm, 275 ± 39.6 µm and 412 ± 26.2 µm in the thin, medium and thick choroid groups, respectively. There was no statistically significant difference in the clinical and imaging features and treatment outcomes between eyes with thin, medium and thick SFCT.

Conclusion

Eyes with PCV can have a choroid of varying thicknesses. Clinical, imaging and treatment responses were similar between the three sub-foveal choroidal thickness groups in this study. In future, more studies are required to evaluate the role of the choroidal thickness and its relationship to treatment in PCV.

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Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We would like to thank our technicians, Mr. Abhishek Bhatt, Mr. Deekshit, Mr. Manjunath and Mr. Madhu for their contribution in acquiring the images and providing them to us for analysis in this study.

Funding

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Authors and Affiliations

  1. Department of Retina-Vitreous, Narayana Nethralaya, 121/C, Chord Road, 1st ‘R’ Block, Rajaji Nagar, Benguluru, 560010, India

    Ramesh Venkatesh, Santosh Gopi Krishna Gadde, Arpitha Pereira, Vivek Singh, Sajjan Sangai, Akhila Sridharan, Bharathi Bavaharan, Nimesh Jain & Naresh Kumar Yadav

Authors
  1. Ramesh Venkatesh
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  2. Santosh Gopi Krishna Gadde
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  3. Arpitha Pereira
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  4. Vivek Singh
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  5. Sajjan Sangai
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  6. Akhila Sridharan
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  7. Bharathi Bavaharan
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  8. Nimesh Jain
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  9. Naresh Kumar Yadav
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Contributions

RV, SGK helped in conceptualizing the study, data acquisition, analyzing the data, interpreting the findings, writing and reviewing the manuscript. NKY helped in reviewing the manuscript. SS, AKI, VS, BVH, NJ helped in data acquisition. AP contributed to data analysis, interpreting the results and reviewing the manuscript.

Corresponding author

Correspondence to Ramesh Venkatesh.

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Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

This article does not contain any studies with animals performed by any of the authors.

Consent for publication

Informed consent was obtained from all individual participants included in the study. The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his/her images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Ethical approval and consent to participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Narayana Nethralaya institutional review board—C-2019-05-006) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Venkatesh, R., Gadde, S.G.K., Pereira, A. et al. Impact of sub-foveal choroidal thickness on clinical features and long-term clinical outcomes in polypoidal choroidal vasculopathy. Int Ophthalmol 41, 87–97 (2021). https://doi.org/10.1007/s10792-020-01555-6

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  • DOI: https://doi.org/10.1007/s10792-020-01555-6

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