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Blood coagulation parameters after intravitreal injection of aflibercept in patients with neovascular age-related macular degeneration

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Abstract

Purpose

The aim of this study was to evaluate the effect of intravitreal injection of aflibercept (IVA) on blood coagulation tests in neovascular age-related macular degeneration (AMD) patients.

Methods

Thirty-four patients with neovascular AMD (study group) and 32 healthy individuals (control group) were enrolled. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured at different times in patients with neovascular AMD.

Results

The levels of PT and aPTT after IVA were decreased at 1 month after the first injection and 1 month after the second injection compared to the baseline measurement in the study group.

Conclusions

IVA may cause a decrease in the levels of PT and aPTT at 1 month after the first injection and 1 month after the second injection although these results are not statistically significant in our study.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Ankara Atatürk Education and Research Hospital, Ankara, Turkey

    Hasan Altinkaynak

  2. Department of Ophthalmology, Yıldırım Beyazıt University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey

    Meltem Ece Kars & Nagihan Ugurlu

  3. Department of Ophthalmology, World Eye Hospital, Ankara, Turkey

    Piraye Zeynep Kurkcuoglu

Authors
  1. Hasan Altinkaynak
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  2. Meltem Ece Kars
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  3. Piraye Zeynep Kurkcuoglu
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  4. Nagihan Ugurlu
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Corresponding author

Correspondence to Hasan Altinkaynak.

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Conflict of interest

The authors declare no financial or proprietary interests.

Ethical approval

The study protocol followed the principles in the declaration of Helsinki.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Altinkaynak, H., Kars, M.E., Kurkcuoglu, P.Z. et al. Blood coagulation parameters after intravitreal injection of aflibercept in patients with neovascular age-related macular degeneration. Int Ophthalmol 38, 2397–2402 (2018). https://doi.org/10.1007/s10792-017-0741-x

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  • DOI: https://doi.org/10.1007/s10792-017-0741-x

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