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Indications and graft survival analysis in optical penetrating keratoplasty in a tertiary care center in North India: a 5-year study

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Abstract

Purpose

To study the indications and variables correlating with graft survival in optical penetrating keratoplasty in a tertiary care hospital in north India.

Participants

All patients who underwent optical keratoplasty, except those undergoing lamellar grafts, tectonic grafts transplants and penetrating keratoplasty done for therapeutic purposes were included in the study. Patients with follow-up less than 2 years were excluded from the study.

Materials and methods

Data were obtained by reviewing the records of 101 patients who underwent optical penetrating keratoplasty from 2008 to 2013 for various indications.

Results

Out of 101 patients who underwent optical penetrating keratoplasty, 71 were males and 30 were females. The mean age of the recipient was 48.53 years with range 1–82 years. The main indications were previous failed graft (29.7%), healed keratitis except HSV (15.8%), pseudophakic or aphakic bullous keratopathy (14.8%), corneal dystrophies/degenerations (12.9%), adherent leucoma (9.9%), post-HSV scars (8.9%), and others like anterior staphyloma, congenital corneal opacities, buphthalmos and keratoconus (7.9%). The graft survival rate was 67.33% at 1-year follow-up and 59.4% at 2-year follow-up. The mean survival time of the grafts was 22.42 months. The mean time for graft failure was 7.12 (±0.9) months.

Conclusion

One- and 2-year survival of grafts at our center is lower as compared to western studies, probably due to higher percentage of poor prognosis indications for surgery and a relative scarcity of excellent-quality donor corneas.

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Funding

No funding was received for this research.

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Authors and Affiliations

  1. Department of Ophthalmology, D Block, Level 3, Government Medical College and Hospital, Sector 32, Chandigarh, 160030, India

    Sudesh Kumar Arya, Amit Raj, Ravi Kant Bamotra, Anubha Bhatti, Jyoti Deswal & Meenakshi Sindhu

Authors
  1. Sudesh Kumar Arya
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  2. Amit Raj
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  3. Ravi Kant Bamotra
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  4. Anubha Bhatti
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  5. Jyoti Deswal
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  6. Meenakshi Sindhu
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Corresponding author

Correspondence to Amit Raj.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership or other equity interest; and expert testimony or patent licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies were in accordance with the 1964 Helsinki declaration. For this type of retrospective study, formal consent was not required. The identifying particulars of participants were not revealed in the study.

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Arya, S.K., Raj, A., Bamotra, R.K. et al. Indications and graft survival analysis in optical penetrating keratoplasty in a tertiary care center in North India: a 5-year study. Int Ophthalmol 38, 1669–1679 (2018). https://doi.org/10.1007/s10792-017-0641-0

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  • DOI: https://doi.org/10.1007/s10792-017-0641-0

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