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Efficacy of systemic diclofenac sodium on intravitreal concentration

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Abstract

Background

Nonsteroidal anti-inflammatory drugs (NSAIDs), as an alternative, are replacing corticosteroids in ocular inflammatory diseases. Diclofenac has been used mainly topically, and recent focus has been on intravitreal delivery. Both of these methods have been shown to have complications in long-term application.

Purpose

To assess the efficacy of slow release oral diclofenac sodium on intravitreal concentration in experimental model of chemically injured eyes.

Methods

In an experimental double-masked clinical trial, right eyes of 24 albino rabbits were chemically injured by 1 N NaOH. One hour after chemical injury, 10 cc suspension gavage containing 100 mg slow release diclofenac sodium was administered in all cases. 2, 4, 6, 12, 24, 48 h after gavage, vitreous samples were obtained in all cases. Intravitreal concentration of diclofenac sodium was evaluated in all samples using high-performance liquid chromatography (HPLC) method.

Results

Intravitreal diclofenac levels by oral intake were enhanced by the inflammation in all the measurements. In inflamed eyes, diclofenac concentration was ten times more than control eye (2.658 ± 0.344 vs. 0.242 ± 0.0279 and 1.617 ± 0.527 vs. 0.148 ± 0.095; in 2 and 4 h, respectively). After 6 h, diclofenac concentration was statistically different, although it reduced below 1 μg/ml.

Conclusion

Diclofenac is delivered to the inflamed eye more than healthy eye. It seems that by oral diclofenac consumption, it is possible to make a significant intravitreal concentration.

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Acknowledgements

This study was conducted under the supervision of National Elite Foundation as “Research Project in Place of Compulsory Military Duty” for Dr. Mojtaba Abrishami and was supported by office of Vice-Chancellor for Research Affairs of Baqiyatallah University of Medical Sciences. The authors would like to thank Zohreh Poursaleh MD and Shahram Parvin MSc for their help in the process of this study and animal lab. It is a pleasure for us to appreciate kindness of Capt. Hasan Ghasemi.

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Authors and Affiliations

  1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Yunes Panahi, Mostafa Naderi & Khosrow Jadidi

  2. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Hadise Hoseini & Mojtaba Abrishami

  3. Farabi Eye Hospital, Qazvin Square, Tehran, 1336616351, Iran

    Mojtaba Abrishami

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  1. Yunes Panahi
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  2. Mostafa Naderi
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Correspondence to Mojtaba Abrishami.

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Panahi, Y., Naderi, M., Jadidi, K. et al. Efficacy of systemic diclofenac sodium on intravitreal concentration. Int Ophthalmol 38, 99–104 (2018). https://doi.org/10.1007/s10792-016-0428-8

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  • DOI: https://doi.org/10.1007/s10792-016-0428-8

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