Abstract
Psoriasis is a non-contagious, chronic, relapsing inflammatory skin disease with cutaneous manifestations such as red, raised scaly plaques. Current treatment approaches for psoriasis comprise topical therapy, systemic therapy, phototherapy, psoralen with UVA(PUVA) and biologics. Regardless of the progression in therapeutic approaches (novel therapies like biologics) in psoriasis, phototherapy is also an economical, compelling and safe treatment option that lacks the immunosuppressive properties as well as the toxicities of traditional modalities. It can be combined safely with other therapeutic options such as topical therapies and novel biologics and provide effective therapy. The aim of the current review is to analyze the literature on the safety as well as the efficacy of phototherapy with various treatment modalities in the management of psoriasis. This review summarizes randomized controlled clinical trials addressing combinations of phototherapy with other treatment modalities for the management of psoriasis. The findings of these clinical studies are elaborated.
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Acknowledgements
The authors would like to acknowledge the research funding support by the Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Government of India to “Pharmaceutical Innovation and Translational Research Lab (PITRL)” Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, India.
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This study was funded by the Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Government of India to National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, India.
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Sreya, R., Nene, S., Pathade, V. et al. Emerging trends in combination strategies with phototherapy in advanced psoriasis management. Inflammopharmacol 31, 1761–1778 (2023). https://doi.org/10.1007/s10787-023-01257-2
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DOI: https://doi.org/10.1007/s10787-023-01257-2