Abstract
Aims
Celecoxib presents a good analgesic effect in patients who undergo arthroscopic rotator cuff repair (ARCR) surgery, while few studies investigate the optimal timing of celecoxib administration. This study aimed to explore the analgesic effect of preoperative versus postoperative administration of celecoxib in ARCR-treated patients.
Methods
A total of 106 ARCR-treated patients were enrolled and randomized at a 1:1 ratio into preoperative analgesia group (N = 53) and postoperative analgesia group (N = 53). The pain visual analog scale (VAS) score at rest or flexion, salvage consumption of pethidine, patient’s satisfaction score, modified University of California at Los Angeles (UCLA) score and adverse events were evaluated.
Results
Pain VAS scores at rest at 12 h and D1 (but not D2, D3 or D7) and pain VAS scores at flexion at 12 h, D1 and D2 (but not D3 or D7) were decreased in preoperative analgesia group compared to postoperative analgesia group. Meanwhile, rescue analgesia rate and 7-day pethidine consumption in preoperative analgesia group were lower than that in postoperative analgesia group. Besides, the overall satisfaction scores at D1 and D3 (but not at D7 or M3) were elevated in preoperative analgesia group compared to postoperative analgesia group. However, no difference of modified UCLA scores at D7 or M3, or the occurrences of adverse events were found between the two groups.
Conclusions
Celecoxib preoperative administration remits acute pain and facilitates satisfaction but does not improve long-term shoulder joint function recovery compared to its postoperative administration in patients who undergo ARCR surgery.
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Data availability
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Funding
This study was supported by Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Program (YB2020041; YB2020042), Scientific Research Project of Wuxi Municipal Health Committee (Q201945), Top Talent Support Program for young and middle-aged people of Wuxi Health Committee (BJ2020066) and Medical and Health Guidance Project of Wuxi Science and Technology Bureau (2020-19).
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This study was approved by the Ethics Committee of Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine.
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10787_2021_893_MOESM1_ESM.tif
Supplementary figure 1. BCr and BUN between the preoperative analgesia group and the postoperative analgesia group. Comparison of BCr (A) between groups before surgery; comparison of BUN (B) between groups before surgery; comparison of BCr (C) between groups after surgery; comparison of BUN (D) between groups after surgery. BCr, blood urea nitrogen/creatinine ratio; BUN, blood urea nitrogen; D, day. (TIF 1169 KB)
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Yang, J., Wang, S., Liu, L. et al. The analgesic effect and safety of preoperative versus postoperative administration of celecoxib in patients who underwent arthroscopic rotator cuff repair: a randomized, controlled study. Inflammopharmacol 30, 185–191 (2022). https://doi.org/10.1007/s10787-021-00893-w
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DOI: https://doi.org/10.1007/s10787-021-00893-w