Abstract
Celecoxib is commonly used for pain management after total hip arthroplasty (THA), while the optimal timing of analgesic celecoxib remains unclear. This randomized, controlled study aimed to investigate the pain control efficacy and safety of preoperative celecoxib versus postoperative celecoxib in osteoarthritis (OA) patients undergoing THA. Totally, 192 hip OA patients about to undergo THA were randomized into pre-treatment group (N = 96) and post-treatment group (N = 96). The former was given 400 mg celecoxib at 4 h before THA, 200 mg at 4 h after THA, and then 200 mg every 12 h until 72 h post-operation. The latter was given 400 mg celecoxib at 4 h after THA, and then 200 mg every 12 h until 72 h post-operation. Pain at rest visual analog scale (VAS) score at 6 h, and pain at flexion VAS scores at 6 h, 12 h, and on D1, D2 were decreased in pre-treatment group compared to post-treatment group (all P < 0.05). Furthermore, additional consumption of patient-controlled analgesia (PCA) (P = 0.006) and total consumption of PCA (P = 0.006) were both reduced in pre-treatment group compared to post-treatment group. Meanwhile, compared to post-treatment group, patient satisfaction in pre-treatment group was higher on D1 (P = 0.010) and D2 (P = 0.039). While, Harris hip score showed no difference between pre-treatment group and post-treatment group on M1 or M3 (both P > 0.05). In conclusion, preoperative celecoxib exhibits better analgesic efficacy and patients’ satisfaction management with similar tolerance compared to postoperative celecoxib in hip OA patients undergoing THA.
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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
Charlesworth J, Fitzpatrick J, Perera NKP, Orchard J (2019) Osteoarthritis—a systematic review of long-term safety implications for osteoarthritis of the knee. BMC Musculoskelet Disord 20:151
Ittichaikulthol W, Prachanpanich N, Kositchaiwat C, Intapan T (2010) The post-operative analgesic efficacy of celecoxib compared with placebo and parecoxib after total hip or knee arthroplasty. J Med Assoc Thai 93:937–942
Jianda X, Yuxing Q, Yi G, Hong Z, Libo P, Jianning Z (2016) Impact of preemptive analgesia on inflammatory responses and rehabilitation after primary total knee arthroplasty: a controlled clinical study. Sci Rep 6:30354
Kahlenberg CA, Patel RM, Knesek M, Tjong VK, Sonn K, Terry MA (2017) Efficacy of celecoxib for early postoperative pain management in hip arthroscopy: a prospective randomized placebo-controlled study. Arthroscopy 33:1180–1185
Karlsen AP, Wetterslev M, Hansen SE, Hansen MS, Mathiesen O, Dahl JB (2017) Postoperative pain treatment after total knee arthroplasty: a systematic review. PLoS ONE 12:e0173107
Khan AM, McLoughlin E, Giannakas K, Hutchinson C, Andrew JG (2004) Hip osteoarthritis: where is the pain? Ann R Coll Surg Engl 86:119–121
Koenig L, Zhang Q, Austin MS, Demiralp B, Fehring TK, Feng C, Mather RC 3rd, Nguyen JT, Saavoss A, Springer BD, Yates AJ Jr (2016) Estimating the societal benefits of THA after accounting for work status and productivity: a markov model approach. Clin Orthop Relat Res 474:2645–2654
Lee JK, Chung KS, Choi CH (2015) The effect of a single dose of preemptive pregabalin administered with COX-2 inhibitor: a trial in total knee arthroplasty. J Arthroplast 30:38–42
Lespasio MJ, Sultan AA, Piuzzi NS, Khlopas A, Husni ME, Muschler GF, Mont MA (2018) Hip osteoarthritis: a primer. Perm J 22:17–084
Liu J, Wang F (2018) Preoperative celecoxib analgesia is more efficient and equally tolerated compared to postoperative celecoxib analgesia in knee osteoarthritis patients undergoing total knee arthroplasty: a randomized, controlled study. Medicine (baltimore) 97:e13663
Long JB, Bevil K, Giles DL (2019) Preemptive analgesia in minimally invasive gynecologic surgery. J Minim Invasive Gynecol 26:198–218
Nilsdotter A, Bremander A (2011) Measures of hip function and symptoms: Harris Hip Score (HHS), Hip Disability and Osteoarthritis Outcome Score (HOOS), Oxford Hip Score (OHS), Lequesne Index of Severity for Osteoarthritis of the Hip (LISOH), and American Academy of Orthopedic Surgeons (AAOS) Hip and Knee Questionnaire. Arthritis Care Res (hoboken) 63(Suppl 11):S200–S207
Reid GD, Reid CG, Widmer N, Munk PL (2010) Femoroacetabular impingement syndrome: an underrecognized cause of hip pain and premature osteoarthritis? J Rheumatol 37:1395–1404
Ren L, Meng L, Yan H, Sun W, Yao D (2020) Preoperative meloxicam versus postoperative meloxicam for pain control, patients’ satisfaction and function recovery in hip osteoarthritis patients who receive total hip arthroplasty: a randomized, controlled study. Inflammopharmacology 28:831–838
Zhang Z, Huang C, Jiang Q, Zheng Y, Liu Y, Liu S, Chen Y, Mei Y, Ding C, Chen M, Gu X, Xing D, Gao M, He L, Ye Z, Wu L, Xu J, Yang P, Zhang X, Zhang Y, Chen J, Lin J, Zhao L, Li M, Yang W, Zhou Y, Jiang Q, Chu CQ, Chen Y, Zhang W, Tsai WC, Lei G, He D, Liu W, Fang Y, Wu D, Lin J, Wei CC, Lin HY, Zeng X (2020) Guidelines for the diagnosis and treatment of osteoarthritis in China (2019 edition). Ann Transl Med 8:1213
Zhu X (2020) Efficacy of preemptive analgesia versus postoperative analgesia of celecoxib on postoperative pain, patients’ global assessment and hip function recovery in femoroacetabular impingement patients underwent hip arthroscopy surgery. Inflammopharmacology 28:131–137
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Pu, C., Jiang, X., Sun, Y. et al. Efficacy and safety between early use and late use of celecoxib in hip osteoarthritis patients who receive total hip arthroplasty: a randomized, controlled study. Inflammopharmacol 29, 1761–1768 (2021). https://doi.org/10.1007/s10787-021-00880-1
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DOI: https://doi.org/10.1007/s10787-021-00880-1