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Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches

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Abstract

Inflammatory bowel disease (IBD) is a collection of inflammatory conditions of colon and small intestine which affect millions of individuals worldwide and the prevalence amount is on the rise. The organ failure as well as loss of tissue function is because of the inflammatory reaction which is the major contributor of tissue healing leading to lifelong debilitation. To stop the tough consequences of inflammation every patient pursues alternative therapy to relieve symptoms. Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-α) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2). This article highlights the green approach regarding the defensive effects of GTP review-related studies concerning the contrary effects and the key therapeutic targets application of GTPs in biomedical field to treat inflammatory bowel disease (IBD) and its complications.

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Abbreviations

GTPs:

Green tea polyphenols

TLR4:

Toll-like receptor 4

COX-2:

Cyclooxygenase-2

IBD:

Inflammatory bowel disease

CED:

Celiac disease

CAM:

Complementary and alternative medicine

UC:

Ulcerative colitis

CD:

Crohn’s disease

TNF-α:

Tumor necrosis factor alpha

NSAIDs:

Non-steroidal anti-inflammatory drugs

IKK:

I kappa B kinase complex

NF-kB:

Nuclear factor-kappa B

NPCs:

Neural progenitor cells

EGCG (−):

Epigallocatechin gallate

EGC (−):

Epigallocatechin

ECG (−):

Epicatechin gallate

EC (−):

Epicatechin

LPL:

Lamina propria lymphocytes

APAP:

Acetaminophen [N-acetyl-p-aminophenol]

C. diff:

Clostridium difficile

Nrf2:

Nuclear factor erythroid 2-related factor

NO:

Nitric oxide

NOS:

Nitric oxide synthases

iNOS:

Inducible nitric oxide synthase

cNOS:

Catalytic nitric oxide synthase

MMP-9:

Matrix metalloproteinase-9

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Acknowledgements

The work was jointly supported by the National Natural Science Foundation of China (No. 31472250), Postdoctoral Science Fund of Anhui Province (2016B117) and the Project of Modern Agricultural Industry and Technology System of Anhui Province (2016–2020). We wish to thank anonymous reviewers for their kind advice.

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  1. Sajid Ur Rahman and Yu Li contributed equally to this study.

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  1. College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, China

    Sajid Ur Rahman, Yu Li, Yingying Huang, Lei Zhu, Shibin Feng, Jinjie Wu & Xichun Wang

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Rahman, S.U., Li, Y., Huang, Y. et al. Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches. Inflammopharmacol 26, 319–330 (2018). https://doi.org/10.1007/s10787-018-0462-4

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