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Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro

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Abstract

Periodontitis is a chronic infectious disease, the course and progression of which are determined by the interaction between microorganisms and the host. Interleukin 1β plays an important role in the destruction of periodontal tissues. Interleukin 1 receptor antagonist (IL-1ra) can inhibit the biological activity of IL-1β without triggering any intracellular signaling. This study aimed to prepare IL-1ra-loaded dextran/PLGA microspheres and evaluate the physical and chemical characteristics and anti-inflammatory properties. Results suggested that the microspheres can be easily prepared into a drug carrier with good biocompatibility and can effectively inhibit the gene expression of pro-inflammatory factors induced by IL-1β in human gingival fibroblasts. Hence, the microspheres are excellent candidate for periodontitis treatment.

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Authors and Affiliations

  1. Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of China

    Jingyi Lu, Baijie Ren, Lei Wang & Yue Liu

  2. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, People’s Republic of China

    Minghe Li

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  1. Jingyi Lu
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Correspondence to Lei Wang.

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The Ethics Committee of Hospital of Stomatology, Jilin University, granted permission to allow the gingival tissues to be removed for HGF, isolation, and culture.

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Lu, J., Ren, B., Wang, L. et al. Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro. Inflammation 43, 168–178 (2020). https://doi.org/10.1007/s10753-019-01107-w

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