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Astragalin Attenuates Allergic Inflammation in a Murine Asthma Model

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Abstract

The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovered in bronchoalveolar lavage fluid, and increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that AG substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot analysis demonstrated that AG treatments markedly inhibited OVA-induced SOCS-3 expression and enhancement of SOCS-5 expression in an asthma model. Our findings support the possible use of AG as a therapeutic drug for patients with allergic asthma.

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The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Pharmacology, Shaanxi University of Chinese Medicine, Xianyang, China, 712046

    Jiping Liu, Yue Cheng, Xiaoshuang Zhang, Xue Zhang, Shuxian Chen, Zongmiao Hu, Chunmei Zhou & Enhu Zhang

  2. Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China, 210009

    Shiping Ma

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  1. Jiping Liu
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  2. Yue Cheng
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  3. Xiaoshuang Zhang
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  4. Xue Zhang
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  5. Shuxian Chen
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  8. Enhu Zhang
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  9. Shiping Ma
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Correspondence to Enhu Zhang or Shiping Ma.

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Liu, J., Cheng, Y., Zhang, X. et al. Astragalin Attenuates Allergic Inflammation in a Murine Asthma Model. Inflammation 38, 2007–2016 (2015). https://doi.org/10.1007/s10753-015-0181-6

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  • DOI: https://doi.org/10.1007/s10753-015-0181-6

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