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Crosstalk between GSK-3β-actuated molecular cascades and myocardial physiology

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An Author Correction to this article was published on 09 July 2020

An Author Correction to this article was published on 08 May 2020

This article has been updated

Abstract

The finding of “glycogen synthase kinase-3” (GSK-3) was initially identified as a protein kinase that phosphorylate and inhibited glycogen synthase. However, it was soon discovered that GSK-3 also has significant impact in regulation of truly astonishing number of critical intracellular signaling pathways ranging from regulation of cell growth, neurology, heart failure, diabetes, aging, inflammation, and cancer. Recent studies have validated the feasibility of targeting GSK-3 for its vital therapeutic potential to maintain normal myocardial homeostasis, conversely, its loss is incompatible with life as it can abrupt cell cycle and endorse fatal cardiomyopathy. The current study focuses on its expanding therapeutic action in myocardial tissue, concentrating primarily on its role in diabetes-associated cardiac complication, apoptosis and metabolism, heart failure, cardiac hypertrophy, and myocardial infarction. The current report also includes the finding of our previous investigation that has shown the impact of GSK-3β inhibitor against diabetes-associated myocardial injury and experimentally induced myocardial infarction. We have also discussed some recent identified GSK-3β inhibitors for their cardio-protective potential. The crosstalk of various underlying mechanisms that highlight the significant role of GSK-3β in myocardial pathophysiology have been discussed in the present report. For these literatures, we will rely profoundly on our previous studies and those of others to reconcile some of the deceptive contradictions in the literature.

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Acknowledgments

The authors are grateful to the authority of the Amity Institute of Pharmacy, Amity University, Haryana-122413, India for providing the necessary facilities.

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Authors and Affiliations

  1. Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, 122413, India

    Arun K. Sharma & Saurabh Bhatia

  2. Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mawz, Oman

    Saurabh Bhatia & Ahmed Al-Harrasi

  3. Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, 110017, India

    Mukesh Nandave

  4. College of Medicine, Physiology Department, King Saud University, Riyadh, Saudi Arabia

    Hanan Hagar

  5. Department of Pharmacology, College of Pharmacy, Zagazig University, Zagazig, Egypt

    Hanan Hagar

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  1. Arun K. Sharma
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Sharma, A.K., Bhatia, S., Al-Harrasi, A. et al. Crosstalk between GSK-3β-actuated molecular cascades and myocardial physiology. Heart Fail Rev 26, 1495–1504 (2021). https://doi.org/10.1007/s10741-020-09961-9

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