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Left ventricular noncompaction, morphological, and clinical features for an integrated diagnosis

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Abstract

The presence of myocardial noncompaction (NC), regardless of the criterion used, does not identify cardiomyopathy per se. The distinction between a morphological variant and the presence of an NC cardiomyopathy is challenging. However, thanks to larger cohorts of patients and longer periods of follow-up, better clinical characterization and prognostic evaluation are becoming available. Indeed, the physician is required to integrate the evidence of NC with the clinical history of the patient, which is supplemented by necessary advanced instrumental investigations before a definite diagnosis of NC cardiomyopathy can be made. Therefore, we extensively revised the current literature in order to help the clinicians to identify clinical features which are pivotal supporting diagnostic element for the correct recognition of Left ventricular noncompaction cardiomyopathy and thus highlighting the difference between a form of cardiomyopathy and a mere intraventricular hypertrabeculation.

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Acknowledgments

This study was supported by the CRTrieste, FINCANTIERI, and GENERALI Foundations to Heart Muscle Diseases Research at Cardiovascular Department, University Hospital of Trieste.

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Authors and Affiliations

  1. Cardiovascular Department, Cardiomyopathy Center, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy

    Francesco Negri, Antonio De Luca, Enrico Fabris, Renata Korcova & Gianfranco Sinagra

  2. Head of Cardio-Neuro-Vascular Department Ca’ Foncello and San Giacomo Hospital Azienda N 2, Marca Trevigiana, Treviso, Italy

    Carlo Cernetti

  3. Fondazione G. Monastiero CNR-Regione Toscana, Pisa, Italy

    Chrysanthos Grigoratos & Giovanni Donato Aquaro

  4. Scuola Superiore Sant’Anna, Institute of Life Sciences, Pisa, Italy

    Chrysanthos Grigoratos

  5. Northwest Heart Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK

    Gaetano Nucifora

  6. Flinders University, Bedford Park, Adelaide, Australia

    Gaetano Nucifora

  7. Vita-Salute University and San Raffaele Hospital, Milan, Italy

    Paolo G. Camici

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  1. Francesco Negri
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Negri, F., De Luca, A., Fabris, E. et al. Left ventricular noncompaction, morphological, and clinical features for an integrated diagnosis. Heart Fail Rev 24, 315–323 (2019). https://doi.org/10.1007/s10741-018-9763-3

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