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Survivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasms

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Abstract

The most prevalent malignant ovarian neoplasms are epithelial ovarian cancers which is the most common cause of death among all gynecologic malignancies and a result of complex interaction of multiple oncogenes and tumor suppressor genes. The aim of this study was to evaluate expression of survivin and cycline D1 biomarkers in mucinous ovarian neoplasms and their correlations with clinicopathological variables in mucinous ovarian cancers. We analyzed pathological specimens of 98 patients with benign (n = 34), borderline (n = 22) and malignant (n = 42) mucinous ovarian neoplasms. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded specimens. Immunohistochemical analysis revealed that survivin and cyclin D1 expressions were located primarily in the nucleus of ovarian tumor cells and relatively weaker cytoplasmic staining. Survivin expression was significantly higher in malignant tumors (88.1 %) than those found in borderline (18.2 %) and benign tumors (8.8 %) (p < 0.001). Similarly, higher cyclin D1 expression was observed in malignant tumors (100 %) compared to borderline (36.4 %) and benign tumors (5.9 %) (p < 0.001). Expression of all biomarkers analyzed significantly and gradually increased from benign to borderline and borderline to malignant mucinous tumors. In terms of clinicopathological variables, tumor grade, FIGO stage and lymph node methastasis were associated with the expression of both biomarkers. Whereas age exhibited no different correlations in mucinous ovarian cancers. The expressions of survivin and cycline D1 are positively correlated with the malignant potential of mucinous ovarian neoplasms.

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Authors and Affiliations

  1. Department of Histology and Embryology, Faculty of Medicine, Istanbul Medeniyet University, 34710, Istanbul, Turkey

    Mehmet Kanter

  2. Department of Pathology, Faculty of Medicine, Selcuk University, Konya, Turkey

    Gulay Turan, H. Hasan Esen & Lema Tavlı

  3. Goztepe Education and Research Hospital, Clinics of Gynecology and Obstetrics, Istanbul Medeniyet University, Istanbul, Turkey

    Ceyda Usta & Akin Usta

  4. Departments of Gynecology and Obstetrics, Faculty of Medicine, Selcuk University, Konya, Turkey

    Cetin Celik

  5. Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey

    Yusuf Demirkol

  6. Faculty of Medicine, Medical University, Sofia, Bulgaria

    Betül Kanter

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  1. Mehmet Kanter
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  2. Gulay Turan
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  3. Ceyda Usta
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  4. Akin Usta
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  5. H. Hasan Esen
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  9. Betül Kanter
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Correspondence to Mehmet Kanter.

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Kanter, M., Turan, G., Usta, C. et al. Survivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasms. J Mol Hist 47, 145–152 (2016). https://doi.org/10.1007/s10735-016-9661-8

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  • DOI: https://doi.org/10.1007/s10735-016-9661-8

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