Abstract
This paper presents a multi-product multi-period stochastic program for an integrated blood supply chain that considers red blood cells and platelets while accounting for multi-product interactions, demand uncertainty, blood age information, blood type substitution, and three types of patients. The aim is to minimize the total cost incurred during the collection, production, inventory, and distribution echelons under centralized control. The supply chains for red blood cells and platelets intertwine at the collection and production echelons as collected whole blood can be separated into red blood cells and platelets at the same time. By adapting to a real-world blood supply chain with one blood center, three collection facilities, and five hospitals, we found a cost advantage of the multi-product model over an uncoordinated model where the red blood cell and platelet supply chains are considered separately. Further sensitivity analyses indicated that the cost savings of the multi-product model mainly come from variations in the number of whole blood donors. These findings suggest that healthcare managers are able to see tremendous improvement in cost efficiency by considering red blood cell and platelet supply chains as a whole, especially with more whole blood donations and a higher percentage of whole blood derived platelets pooled for transfusion.
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References
Abbasi B, Hosseinifard SZ (2014) On the Issuing Policies for Perishable Items such as Red Blood Cells and Platelets in Blood Service. Decis Sci 45(5):995–1020
Abdulwahab U, Wahab MIM (2014) Approximate dynamic programming modeling for a typical blood platelet bank. Comput Ind Eng 78:259–270. https://doi.org/10.1016/j.cie.2014.07.017
Altiparmak F, Gen M, Lin L, Karaoglan I (2009) A steady-state genetic algorithm for multi-product supply chain network design. Comput Ind Eng 56(2):521–537. https://doi.org/10.1016/j.cie.2007.05.012
American Red Cross (2019) Know the facts about blood and blood types. https://www.redcrossblood.org/donate-blood/blood-types.html. Accessed 10 Oct 2019
American Red Cross (2021a) Blood components. https://www.redcrossblood.org/donate-blood/how-to-donate/types-of-blood-donations/blood-components.html. Accessed 25 Oct 2021
American Red Cross (2021b) Blood needs and blood supply. https://www.redcrossblood.org/donate-blood/how-to-donate/how-blood-donations-help/blood-needs-blood-supply.html. Accessed 25 Oct 2021
American Red Cross (2021c) Types of blood donations. https://www.redcrossblood.org/donate-blood/how-to-donate/types-of-blood-donations.html. Accessed 25 Oct 2021
Arvan M, Tavakoli-Moghadam R, Abdollahi M (2015) Designing a bi-objective and multi-product supply chain network for the supply of blood. Uncertain Supply Chain Management 3(1):57–68. https://doi.org/10.5267/j.uscm.2014.8.004
Barbee IW (2013) The 2011 National Blood Collection and Utilization Survey Report. https://www.hhs.gov/sites/default/files/ash/bloodsafety/2011-nbcus.pdf. Accessed 25 Mar 2022
Barbee IW, Srijana R, Andrea H (2015) The 2013 AABB Blood Collection, Utilization, and Patient Blood Management Survey Report. https://www.aabb.org/docs/default-source/default-document-library/resources/2013-aabb-blood-survey-report.pdf?sfvrsn=17317db0_0. Accessed 25 Mar 2022
Beliën J, Forcé H (2012) Supply chain management of blood products: A literature review. Eur J Oper Res 217(1):1–16. https://doi.org/10.1016/j.ejor.2011.05.026
Birge JR, Louveaux F (2011) Introduction to stochastic programming. Springer Science & Business Media. http://www.springer.com/series/3182. Accessed 10 Oct 2019
Civelek I, Karaesmen I, Scheller-Wolf A (2015) Blood platelet inventory management with protection levels. Eur J Oper Res 243(3):826–838. https://doi.org/10.1016/j.ejor.2015.01.023
Deuermeyer BL, Pierskalla WP (1978) A By-Product Production System with an Alternative. Manag Sci 24(13):1373–1383
Dillon M, Oliveira F, Abbasi B (2017) A two-stage stochastic programming model for inventory management in the blood supply chain. Int J Prod Econ 187:27–41. https://doi.org/10.1016/j.ijpe.2017.02.006
Duan Q, Liao TW (2013) A new age-based replenishment policy for supply chain inventory optimization of highly perishable products. Int J Prod Econ 145(2):658–671. https://doi.org/10.1016/j.ijpe.2013.05.020
Duan Q, Liao TW (2014) Optimization of blood supply chain with shortened shelf lives and ABO compatibility. Int J Prod Econ 153:113–129. https://doi.org/10.1016/j.ijpe.2014.02.012
Ensafian H, Yaghoubi S (2017) Robust optimization model for integrated procurement , production and distribution in platelet supply chain. Transp Res E 103:32–55. https://doi.org/10.1016/j.tre.2017.04.005
Ensafian H, Yaghoubi S, Modarres M (2017) Raising quality and safety of platelet transfusion services in a patient-based integrated supply chain under uncertainty. Comput Chem Eng 106:355–372. https://doi.org/10.1016/j.compchemeng.2017.06.015
Eskandari-Khanghahi M, Tavakkoli-Moghaddam R, Taleizadeh AA, Amin SH (2018) Designing and optimizing a sustainable supply chain network for a blood platelet bank under uncertainty. Eng Appl Artif Intell 71(March):236–250. https://doi.org/10.1016/j.engappai.2018.03.004
Fahimnia B, Jabbarzadeh A, Ghavamifar A, Bell M (2017) Supply chain design for efficient and effective blood supply in disasters. Int J Prod Econ 183:700–709. https://doi.org/10.1016/j.ijpe.2015.11.007
Govender P, Ezugwu AE (2019) A Symbiotic Organisms Search Algorithm for Optimal Allocation of Blood Products. IEEE Access 7:2567–2588. https://doi.org/10.1109/ACCESS.2018.2886408
Gunpinar S, Centeno G (2015) Stochastic integer programming models for reducing wastages and shortages of blood products at hospitals. Comput Oper Res 54:129–141. https://doi.org/10.1016/j.cor.2014.08.017
Haijema R, Van Der Wal J, Van Dijk NM (2007) Blood platelet production: Optimization by dynamic programming and simulation. Comput Oper Res 34(3):760–779. https://doi.org/10.1016/j.cor.2005.03.023
Hamdan B, Diabat A (2019) A two-stage multi-echelon stochastic blood supply chain problem. Comput Oper Res 101:130–143. https://doi.org/10.1016/j.cor.2018.09.001
Hosseinifard Z, Abbasi B, Fadaki M, Clay NM (2019) Postdisaster Volatility of Blood Donations in an Unsteady Blood Supply Chain. Decis Sci. https://doi.org/10.1111/deci.12381
Liang T-F (2008) Fuzzy multi-objective production/ distribution planning decisions with multi-product and multi-time period in a supply chain. Comput Ind Eng 55:676–694. https://doi.org/10.1016/j.cie.2008.02.008
Mirzapour Al-E-Hashem SMJ, Malekly H, Aryanezhad MB (2011) A multi-objective robust optimization model for multi-product multi-site aggregate production planning in a supply chain under uncertainty. Int J Prod Econ 134(1):28–42. https://doi.org/10.1016/j.ijpe.2011.01.027
Najafi M, Ahmadi A, Zolfagharinia H (2017) Blood inventory management in hospitals: Considering supply and demand uncertainty and blood transshipment possibility. Operations Research for Health Care 15:43–56. https://doi.org/10.1016/j.orhc.2017.08.006
Osorio AF, Brailsford SC, Smith HK (2015) A structured review of quantitative models in the blood supply chain: a taxonomic framework for decision-making. Int J Prod Res 1(1):1–22. https://doi.org/10.1080/00207543.2015.1005766
Osorio, A. F., Brailsford, S. C., Smith, H. K., Forero-Matiz, S. P., & Camacho-Rodríguez, B. A. (2016). Simulation-optimization model for production planning in the blood supply chain. Health Care Management Science, 122. https://doi.org/10.1007/s10729-016-9370-6
Paksoy T, Bektaş T, Özceylan E (2011) Operational and environmental performance measures in a multi-product closed-loop supply chain. Transportation Research Part E: Logistics and Transportation Review 47(4):532–546. https://doi.org/10.1016/j.tre.2010.12.001
Pirabán, A., Guerrero, W. J., & Labadie, N. (2019). Survey on blood supply chain management: Models and methods. Comput Oper Res, 112. https://doi.org/10.1016/j.cor.2019.07.014
Rajendran S, Ravindran AR (2019) Inventory management of platelets along blood supply chain to minimize wastage and shortage. Comput Ind Eng 130(July 2018):714–730. https://doi.org/10.1016/j.cie.2019.03.010
Rajendran S, Srinivas S (2020) Hybrid ordering policies for platelet inventory management under demand uncertainty. IISE Transactions on Healthcare Systems Engineering 10(2):113–126. https://doi.org/10.1080/24725579.2019.1686718
Van Dijk N, Haijema R, Van Der Wal J, Sibinga CS (2009) Blood platelet production: A novel approach for practical optimization. Transfusion 49(3):411–420. https://doi.org/10.1111/j.1537-2995.2008.01996.x
Wang K-M, Ma Z-J (2015) Age-based policy for blood transshipment during blood shortage. Transportation Research Part E: Logistics and Transportation Review 80:166–183. https://doi.org/10.1016/j.tre.2015.05.007
World Health Organization. (2020). 10 facts on blood transfusion. https://www.who.int/features/factfiles/blood_transfusion/blood_transfusion/en/. Accessed 15 June 2020
Zahiri B, Pishvaee MS (2017) Blood supply chain network design considering blood group compatibility under uncertainty. Int J Prod Res 55(5):2013–2033. https://doi.org/10.1080/00207543.2016.1262563
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Xu, Y., Szmerekovsky, J. A multi-product multi-period stochastic model for a blood supply chain considering blood substitution and demand uncertainty. Health Care Manag Sci 25, 441–459 (2022). https://doi.org/10.1007/s10729-022-09593-5
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DOI: https://doi.org/10.1007/s10729-022-09593-5