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The Rotterdam Study. Design update and major findings between 2020 and 2024

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Abstract

The Rotterdam Study is a population-based cohort study, started in 1990 in the district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the prevalence and incidence, unravel the etiology, and identify targets for prediction, prevention or intervention of multifactorial diseases in mid-life and elderly. The study currently includes 17,931 participants (overall response rate 65%), aged 40 years and over, who are examined in-person every 3 to 5 years in a dedicated research facility, and who are followed-up continuously through automated linkage with health care providers, both regionally and nationally. Research within the Rotterdam Study is carried out along two axes. First, research lines are oriented around diseases and clinical conditions, which are reflective of medical specializations. Second, cross-cutting research lines transverse these clinical demarcations allowing for inter- and multidisciplinary research. These research lines generally reflect subdomains within epidemiology. This paper describes recent methodological updates and main findings from each of these research lines. Also, future perspective for coming years highlighted.

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Funding

Since 2018 the Rotterdam Study has been designated a Core Facility by the Erasmus MC. As Core Facility the Rotterdam Study receives infrastructural funding directly from the institute that covers a part of its basic funding. The remaining infrastructural costs are covered by the participating departments and institutes. External funding is acquired primarily to fund ongoing and well-delineated scientific projects within the Rotterdam Study and is mainly obtained on project-basis. Important external fundings bodies include – but are certainly not limited to – Netherlands Research Organization (NWO), Netherlands Organization for Health Research and Development (ZonMw), European Commission (FP6, FP7, Horizon2020, ERC), and National Institute of Health (NIH).

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Authors and Affiliations

  1. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands

    M. Arfan Ikram, Brenda C.T. Kieboom, Guy Brusselle, Mohsen Ghanbari, Maryam Kavousi, Annemarie I. Luik, Frank J.A. van Rooij, Trudy Voortman & Natalie Terzikhan

  2. Department of Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands

    Willem Pieter Brouwer & Rob J. de Knegt

  3. Department of Pulmonology, University Hospital Ghent, Ghent, Belgium

    Guy Brusselle

  4. Department of Epidemiology, and Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands

    Layal Chaker

  5. Department of Otorhinolaryngology and Head & Neck Surgery, Erasmus MC University Medical Center, Rotterdam, Netherlands

    André Goedegebure

  6. Department of Epidemiology, and Department of Neurology, Erasmus MC University Medical Center, Rotterdam, Netherlands

    M. Kamran Ikram

  7. Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands

    Joyce van Meurs

  8. Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, Netherlands

    Luba M. Pardo

  9. Department of Medicine, and Department of Oral & Maxillofacial Surgery, Erasmus MC University Medical Center, Rotterdam, Netherlands

    Fernando Rivadeneira

  10. Department of Epidemiology, and Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands

    Meike W. Vernooij

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Ikram, M.A., Kieboom, B.C., Brouwer, W.P. et al. The Rotterdam Study. Design update and major findings between 2020 and 2024. Eur J Epidemiol 39, 183–206 (2024). https://doi.org/10.1007/s10654-023-01094-1

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