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Relationship between biomarkers and endocrine-disrupting compounds in wild Girardnichthys viviparus from two lakes with different degrees of pollution

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Abstract

Despite great efforts worldwide to evaluate the effects of endocrine-disrupting compounds (EDCs) in fish, there is little information available about the interactions of EDCs with the disruption of the sexual endocrine axis in fish species with matrotrophic viviparity and intraluminal gestation. To understand these interactions, six sampling campaigns were performed within a period of 1 year in two lakes with different degrees of pollution. A battery of biomarkers of the oestrogenic response was assessed in the liver [vitellogenin, CYP 1A1, epoxide hydrolase activity, and metallothioneins (MT)] and MT in the head of Girardinichthys viviparus. Linear correlation analysis and canonical correspondence analysis were performed to explore the relationship between the oestrogenic response with EDCs and with metals. The biomarker responses were assessed using the water content of EDCs (oestrone, 17-β-oestradiol, oestriol, 17-α-ethinyl oestradiol, total phenols, bisphenol A, nonyl phenol, octyl phenol), as well as the PAHs indene[1,2,3-c,d]pyrene, naphthalene, pyrene, benzo[a]anthracene, benzo[k]fluoranthene and benzo[a]pyrene) and metals (Cu, Fe, Mn, Pb and Zn). Greater disruption of the sexual endocrine axis occurred in fish of both sexes inhabiting the polluted lake whose effects were apparently influenced by CYP 1A1 activity and by 17-α-ethinyl oestradiol. In addition, non-estrogenic mechanisms in the hypothalamus and pituitary glands in male fish were observed, elicited by endogenous levels and the water concentration of Pb. In contrast, in females from the less polluted lake, VTG induction was related to exogenous oestrogens. The disruption of the hypothalamic–pituitary–gonadal axis is a complex process influenced by both endogenous and exogenous factors and contributes to male feminisation by exposure to EDCs.

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Acknowledgments

This study was financed by CONACyT-ICyTDF, code 121184. H.F. Olivares-Rubio and R. Dzul-Caamal are DSc students who receive scholarships from CONACyT. M.E. Gallegos-Rangel and R.L. Madera-Sandoval are MSc students who receive scholarships from CONACyT. M.L. Domínguez-López, E. García-Latorre and A. Vega-López are fellows of Estímulos al Desempeño en Investigación and Comisión y Fomento de Actividades Académicas (Instituto Politécnico Nacional) and Sistema Nacional de Investigadores (SNI, CONACyT, México).

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Laboratorio de Toxicología Ambiental, Escuela Nacional de Ciencias Biológicas, IPN, Wilfrido Massieu s/n, Unidad Profesional Zacatenco, CP 07839, Mexico, DF, Mexico

    Hugo F. Olivares-Rubio, Ricardo Dzul-Caamal, María Esperanza Gallegos-Rangel, Ruth L. Madera-Sandoval & Armando Vega-López

  2. Laboratorio de Inmunoquímica I, Escuela Nacional de Ciencias Biológicas, IPN, Carpio y Plan de Ayala s/n, Plutarco Elías Calles “Casco de Santo Tomás”, CP 11340, Mexico, DF, Mexico

    María Lilia Domínguez-López & Ethel García-Latorre

Authors
  1. Hugo F. Olivares-Rubio
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  2. Ricardo Dzul-Caamal
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  3. María Esperanza Gallegos-Rangel
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  4. Ruth L. Madera-Sandoval
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  5. María Lilia Domínguez-López
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  6. Ethel García-Latorre
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  7. Armando Vega-López
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Corresponding author

Correspondence to Armando Vega-López.

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Olivares-Rubio, H.F., Dzul-Caamal, R., Gallegos-Rangel, M.E. et al. Relationship between biomarkers and endocrine-disrupting compounds in wild Girardnichthys viviparus from two lakes with different degrees of pollution. Ecotoxicology 24, 664–685 (2015). https://doi.org/10.1007/s10646-014-1414-4

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  • DOI: https://doi.org/10.1007/s10646-014-1414-4

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