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Short-term outcomes of induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) in locally advanced nasopharyngeal carcinoma

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Summary

There is an unmet need for improving survival outcomes of locally advanced nasopharyngeal carcinoma, for example, T4/ N3 stage disease. To this end, we administered induction chemotherapy (IC) with TPF (docetaxel, cisplatin, and fluorouracil) because this stage of disease is associated with a high risk of recurrence and is difficult to control with standard treatments, such as chemoradiotherapy (CRT) alone or CRT followed by adjuvant chemotherapy. The aim of this retrospective single-center study was to clarify the short-term outcomes of locally far-advanced nasopharyngeal carcinoma patients treated with IC-TPF, followed by CRT with cisplatin. Data from 11 patients were extracted from our database, indicating that the overall response rate to IC-TPF, clinical complete response rate after CRT, 1-year progression-free survival, and 1-year overall survival were 73%, 91%, 68%, and 89%, respectively. Hematological toxicity was the most common adverse event reported during IC-TPF with 64% of patients suffering grade 3 or 4 neutropenia, 55% grade 3 or 4 leucopenia and 9% febrile neutropenia. Despite the small number of patients, these data are important because there is a limited number of studies investigating IC-TPF followed by CRT in Japanese patients. This pilot study provides some indication of the short-term effectiveness and toxicity of this therapeutic approach, which may be superior to standard treatments. Long-term follow-up is warranted to assess the effectiveness of IC-TPF in terms of clinical outcome and late-phase toxicity.

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Data availability

All data are available upon reasonable request.

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Acknowledgements

We thank Ms. Emiko Usami and Ms. Erika Kato for data collection.

Author information

Authors and Affiliations

  1. Head and Neck Medical Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan

    Shigemasa Takamizawa, Yoshitaka Honma, Hiroki Oka, Shun Yamamoto & Ken Kato

  2. Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan

    Naoya Murakami, Tairo Kashihara & Jun Itami

  3. Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan

    Taisuke Mori

  4. Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan

    Kimiteru Ito & Yuko Kubo

  5. Department of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan

    Atsuo Ikeda, Fumihiko Matsumoto, Go Omura, Kenya Kobayashi & Seiichi Yoshimoto

Authors
  1. Shigemasa Takamizawa
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  2. Yoshitaka Honma
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  3. Naoya Murakami
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  4. Taisuke Mori
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  5. Hiroki Oka
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  6. Shun Yamamoto
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  7. Tairo Kashihara
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  8. Kimiteru Ito
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  9. Yuko Kubo
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  10. Atsuo Ikeda
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  11. Fumihiko Matsumoto
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  12. Go Omura
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  13. Kenya Kobayashi
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  14. Jun Itami
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  15. Ken Kato
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  16. Seiichi Yoshimoto
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Contributions

Authors belonging to Department 1) administered chemotherapy. Authors belonging to Department 2) administered radiotherapy. Authors belonging to Department 3) were responsible for the pathological diagnosis. Authors belonging to Department 4) were responsible for the imaging diagnosis and staging. Authors belonging to Department 5) performed the biopsies and surgery.

Corresponding author

Correspondence to Yoshitaka Honma.

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Conflicts of interest/Competing interests

The authors do not have any potential conflicts of interest to disclose.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This retrospective study was approved by the Institutional Review Board of the National Cancer Center Hospital (2018–168).

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All authors consent to the publication of this study.

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Takamizawa, S., Honma, Y., Murakami, N. et al. Short-term outcomes of induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) in locally advanced nasopharyngeal carcinoma. Invest New Drugs 39, 564–570 (2021). https://doi.org/10.1007/s10637-020-00999-y

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  • DOI: https://doi.org/10.1007/s10637-020-00999-y

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