Abstract
Purpose
To establish reproducibility of multifocal visual evoked potential (mfVEP) and traditional pattern-reversal VEP (tVEP) in normals and relapsing–remitting multiple sclerosis (RRMS).
Methods
mfVEP (60-sector dartboard) was recorded twice within a month in 40 normals and 40 RRMS patients [25 eyes with last optic neuritis (ON) ≥6 months, 34 non-ON]. mfVEP amplitude and latency (ms) were calculated as mean logSNR and median relative latency, respectively, for all 60 sectors (global) and 9 regions. tVEP was recorded (15′, 60′ and 120′ checks) in subsets of 34 normals and 30 RRMS patients. tVEP N75–P100 amplitude (µV) and P100 latency (ms) were obtained. Reproducibility was evaluated using intraclass correlation coefficient (ICC) and test–retest variability (TRV). ICC ≥ 0.75 was considered good.
Results
ICCs for global and regional mfVEP were >0.80 in all groups. ICCs for tVEP were >0.75 for all except latency in ON (0.52–0.68). For mfVEP or tVEP, TRV for amplitude was similar among all groups; TRV for latency (ms) was larger in ON (5.3 for mfVEP global, 10.3 for 60′ tVEP) compared with non-ON (3.1, 8.3) and normal (2.3, 5.7) (p < 0.05 for all). When tVEP was analyzed using similar methods as mfVEP (logSNR and relative latency), mfVEP global measures showed better ICC and TRV than tVEP in all groups.
Conclusions
mfVEP and tVEP showed good reproducibility in normals and RRMS. TRV for mfVEP latency was larger in ON than normal or non-ON. mfVEP global latency’s TRV was about half the respective values for tVEP in all groups, due to averaging of multiple responses.
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Acknowledgments
The authors would like to thank Dr. Courtney Perry for her help in collecting some of the normal subject’s data. This study was supported by NIH P30 EY 007551, NIH T35 EY 007088, Fight for Sight summer student fellowship and the Minnie Flaura Turner memorial fund for impaired vision research.
Conflict of interest
The authors declare that they have no conflicts of interest and have full control of all primary data that could be reviewed by the journal if needed.
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Narayanan, D., Cheng, H., Tang, R.A. et al. Reproducibility of multifocal visual evoked potential and traditional visual evoked potential in normal and multiple sclerosis eyes. Doc Ophthalmol 130, 31–41 (2015). https://doi.org/10.1007/s10633-014-9467-5
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DOI: https://doi.org/10.1007/s10633-014-9467-5