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Incidence and Clinical Outcomes of Inflammatory Bowel Disease in South Korea, 2011–2014: A Nationwide Population-Based Study

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Abstract

Background

The incidence of inflammatory bowel disease (IBD) is increasing in East Asia; however, population-based data from this region are lacking.

Aim

We conducted a nationwide, population-based study to examine the incidence and disease course of IBD in South Korea.

Methods

Using the National Health Insurance claims data, we collected data on patients diagnosed with IBD [10,049 with ulcerative colitis (UC) and 5595 with Crohn’s disease (CD)] from 2011 to 2014.

Results

During the study period, the average annual incidence of UC was 5.0 per 105, while that of CD was 2.8 per 105. Among patients with UC, the cumulative rates of surgery 1 and 4 years after diagnosis were 1.0 and 2.0%; those among patients with CD were 9.0 and 13.9%, respectively. The 1- and 4-year cumulative rates of moderate- to high-dose corticosteroid use were, respectively, 26.6 and 45.2% among patients with UC, and 29.9 and 50.8% among those with CD. Similarly, the 1- and 4-year cumulative rates of immunomodulator use were 14.1 and 26.4% among patients with UC, and 58.3 and 76.1% among those with CD, respectively. With regard to biologic use, the 1- and 4-year cumulative rates were 3.0 and 9.0% among patients with UC, and 11.1 and 31.7% among those with CD, respectively.

Conclusions

The recent incidence of IBD in South Korea has been the highest in East Asia. Patients who had been diagnosed recently with IBD showed lower rates of surgery and higher rates of immunomodulator and biologic use compared to those reported ever in South Korea.

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Acknowledgments

This research was supported by two Grants (A120176 and HI13C1345) from the Korean Health Technology R&D Project of the Korean Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health and Welfare of the Republic of Korea. We also received two Grants (NRF-2013R1A2A2A01067123 and NRF-2014R1A1A1008096) from the Basic Science Research Program of the National Research Foundation of Korea, which is funded by the Ministry of Science, ICT, and Future Planning. Finally we were provided with a Faculty Research Grant (2012-31-0477) from the Department of Internal Medicine, Yonsei University College of Medicine.

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Author notes

  1. Yoon Suk Jung and Minkyung Han have contributed equally to this study.

Authors and Affiliations

  1. Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Yoon Suk Jung

  2. Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea

    Minkyung Han

  3. Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea

    Won Ho Kim & Jae Hee Cheon

  4. Department of Biostatistics, Graduate School of Public Health, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea

    Sohee Park

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  1. Yoon Suk Jung
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Corresponding authors

Correspondence to Sohee Park or Jae Hee Cheon.

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Jung, Y.S., Han, M., Kim, W.H. et al. Incidence and Clinical Outcomes of Inflammatory Bowel Disease in South Korea, 2011–2014: A Nationwide Population-Based Study. Dig Dis Sci 62, 2102–2112 (2017). https://doi.org/10.1007/s10620-017-4640-9

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  • DOI: https://doi.org/10.1007/s10620-017-4640-9

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