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Modified Neoflavones Based on 7-Hydroxyneoflavone-6-Enamino Ketone and 7-Hydroxy-3-Hetarylbenzopyran-2- and 4-Ones Mannich Bases and Their Recyclization

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Chemistry of Natural Compounds Aims and scope

The interaction of 7-hydroxyneoflavone-6-enamino ketone with 8-dialkylamino-7-hydroxy-3-hetarylbenzopyran-2- and 4-ones led to the formation of 10-methyl-4-phenyl-2H,6H-pyrano[3,2-g]-chromen-2,6-dione, which incorporated coumarin or chromone fragments at C-7 using a methylene linker. The recyclization of 7-[3-(1,3-benzothiazol-2-yl)-7-hydroxy-2-oxo-2H-8-chromenylmethyl]-10-methyl-4-phenyl-2H,6H-pyrano[3,2-g]chromene-2,6-dione and 7-[6-ethyl-7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-4-oxo-4H-8-chromenylmethyl]-10-methyl-4-phenyl-2H,6H-pyrano[3,2-g]chromene-2,6-dione was investigated under the influence of N,N- and N,O-binucleophiles.

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Authors and Affiliations

  1. Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska St., Kyiv, 01601, Ukraine

    E. K. Hlibov, N. V. Gorbulenko, V. S. Moskvina, O. V. Shablykina, T. V. Shokol, A. V. Kozytskyi & V. P. Khilya

  2. Enamine Ltd., 78 Chervonotkatska St., Kyiv, 02094, Ukraine

    E. K. Hlibov & A. V. Kozytskyi

  3. V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Akademician Kukhar St., Kyiv, 02094, Ukraine

    V. S. Moskvina & O. V. Shablykina

Authors
  1. E. K. Hlibov
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  2. N. V. Gorbulenko
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  3. V. S. Moskvina
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  4. O. V. Shablykina
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  5. T. V. Shokol
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  6. A. V. Kozytskyi
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  7. V. P. Khilya
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Correspondence to V. S. Moskvina.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2024, pp. 196–201.

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Hlibov, E.K., Gorbulenko, N.V., Moskvina, V.S. et al. Modified Neoflavones Based on 7-Hydroxyneoflavone-6-Enamino Ketone and 7-Hydroxy-3-Hetarylbenzopyran-2- and 4-Ones Mannich Bases and Their Recyclization. Chem Nat Compd 60, 223–228 (2024). https://doi.org/10.1007/s10600-024-04293-8

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  • DOI: https://doi.org/10.1007/s10600-024-04293-8

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