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Newly Synthesized N-Glycosidic Halochalcones Reveal Inhibitory Activity on Pancreatic Triacylglycerol Lipase

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Chemistry of Natural Compounds Aims and scope

In this study, the aim was to synthesize N-glycosidic halochalcone derivatives and to examine their lipase inhibitory activity. The synthesized chalcones (1–3) were well known and the data were compatible with previous findings. However, compounds 4a/b, 5a/b, 6a/b, and 7–9 were synthesized for the first time in the current study. Remarkable lipase inhibitory potentials of the synthesized compounds were further confirmed through molecular docking studies. The highest lipase inhibition activity was experimentally identified for compounds 2 and 5a with IC50 17.7133 ± 0.9648 μg/mL and IC50 22.6521 ± 1.2146 μg/mL, respectively.

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Acknowledgment

For funding we acknowledge Karadeniz Technical University Scientific Research Projects Unit (Project No. TYL-2021-9443).

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey

    M. Yikilmaz, M. Badem, S. Kanbolat & R. Aliyazicioglu

  2. Faculty of Health Sciences, Avrasya University, Trabzon, Turkey

    S. Fandakli

  3. Department of Pharmacognosy, Faculty of Pharmacy, University of Health Sciences, Ankara, Turkey

    S. O. Sener

  4. Department of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey

    N. Yayli

  5. Department of Molecular Biology and Genetics, Faculty of Science, Karadeniz Technical University, Trabzon, Turkey

    U. Uzuner

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  1. M. Yikilmaz
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  4. M. Badem
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Correspondence to R. Aliyazicioglu.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2023, pp. 530–536.

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Yikilmaz, M., Fandakli, S., Sener, S.O. et al. Newly Synthesized N-Glycosidic Halochalcones Reveal Inhibitory Activity on Pancreatic Triacylglycerol Lipase. Chem Nat Compd 59, 629–637 (2023). https://doi.org/10.1007/s10600-023-04075-8

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  • DOI: https://doi.org/10.1007/s10600-023-04075-8

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