One new phenolic glycoside (1) and two known stereoisomers (2 and 3) were isolated from the methanol extract of Viburnum cylindricum leaves. Their structures were determined as (7R,8S)-guaiacylglycerol 9-O-β-D-glucopyranoside (1), (7S,8R)-guaiacylglycerol 9-O-β-D-glucopyranoside (2), and (7R,8R)-guaiacylglycerol 9-O-β-D-glucopyranoside (3), respectively, by spectroscopic data (1D, 2D NMR, HR-ESI-MS, and ORD) and chemical methods. In addition, compound 1 showed potential α-glucosidase inhibitory activity with the IC50 value of 10.73 μM in comparison with the positive control acarbose (IC50 = 18.84 μM).
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Acknowledgment
This work was supported by the Open Foundation of Green Pesticides and Biotechnology Key Laboratory of Guizhou University of the Ministry of Education (2021GDGP0103/2021GDGP0104).
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2023, pp. 234–235.
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Zhang, XH., Chen, J., Tang, YY. et al. A New Phenolic Glycoside with α-Glucosidase Inhibitory Activity from Viburnum cylindricum Leaves. Chem Nat Compd 59, 275–277 (2023). https://doi.org/10.1007/s10600-023-03975-z
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DOI: https://doi.org/10.1007/s10600-023-03975-z