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Diterpenoids from the Seeds of Euphorbia lathyris and their in Vitro Anti-HIV Activity

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Chemistry of Natural Compounds Aims and scope

We have systematically investigated the chemical constituents of E. lathyris from Hebei Province. Consequently, a new ingenane-type diterpenoid (1) was isolated, together with 17 known diterpenoids (2–18). The structures of these compounds were established by NMR spectra and comparison with the literature. The anti-HIV activity of ethanol extracts of the seeds of Euphorbia lathyris from different origins was evaluated. The results showed that all the ethanol extracts exhibited significant anti-HIV activity. The anti-HIV activity of the 18 compounds was determined, but all of the compounds were inactive against HIV viral replication.

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Acknowledgment

This work was supported by the National Natural Science Foundation of China (21572082, U1602222) and the Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization (FPRU2016-8).

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Authors and Affiliations

  1. Faculty of Life Science and Technology, Kunming University of Science and Technology, 650500, Kunming, P. R. China

    Siyi Wang, Hongmei Li, Dan Liu, Qun Zhao, Tao Yang, Rongtao Li & Xuanqin Chen

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  1. Siyi Wang
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  2. Hongmei Li
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  3. Dan Liu
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  4. Qun Zhao
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  5. Tao Yang
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  6. Rongtao Li
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  7. Xuanqin Chen
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Correspondence to Xuanqin Chen.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2020, pp. 72–77.

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Wang, S., Li, H., Liu, D. et al. Diterpenoids from the Seeds of Euphorbia lathyris and their in Vitro Anti-HIV Activity. Chem Nat Compd 56, 78–85 (2020). https://doi.org/10.1007/s10600-020-02948-w

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  • DOI: https://doi.org/10.1007/s10600-020-02948-w

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