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Synthesis of Conjugates of the Alkaloids Cytisine and Lupinine

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Chemistry of Natural Compounds Aims and scope

New potentially biologically active conjugates of the quinolizidine alkaloids cytisine and lupinine linked through succinic or glutaric acid were synthesized.

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References

  1. D. J. Newman and G. M. Cragg, J. Nat. Prod., 75, 311 (2012).

    Article  CAS  Google Scholar 

  2. J. Rouden, M. C. Lasne, J. Blanchet, and J. Baudoux, Chem. Rev., 114, 712 (2014).

    Article  CAS  Google Scholar 

  3. Sh. B. Rakhimov, V. I. Vinogradova, Yu. R. Mirzaev, N. L. Vypova, and D. S. Kazantseva, Chem. Nat. Compd., 42, 462 (2006).

    Article  CAS  Google Scholar 

  4. I. P. Tsypysheva, A. V. Koval’skaya, N. S. Makara, A. N. Lobov, I. A. Petrenko, E. G. Galkin, T. A. Sapozhnikova, F. S. Zarudii, and M. S. Yunusov, Chem. Nat. Compd., 48, 629 (2012).

    Article  CAS  Google Scholar 

  5. N. S. Makara, S. F. Gabdrakhmanova, T. A. Sapozhnikova, R. Yu. Khisamutdinova, A. V. Koval’skaya, I. P. Tsypysheva, and F. S. Zarudii, Pharm. Chem. J., 49 (5), 301 (2015).

    Article  CAS  Google Scholar 

  6. I. P. Tsypysheva, A. V. Koval’skaya, A. N. Lobov, V. V. Zarubaev, L. A. Karpinskaya, I. A. Petrenko, E. A. Nikolaeva, A. A. Shtro, and M. S. Yunusov, Chem. Nat. Compd., 48, 1042 (2012).

    Article  Google Scholar 

  7. A. K. Przybyl, E. Maj, J. Wietrzyk, and M. Kubicki, J. Mol. Struct., 1176, 871 (2019).

    Article  CAS  Google Scholar 

  8. Yu. V. Vakhitova, E. I. Farafontova, L. F. Zainullina, V. A. Vakhitov, I. P. Tsypysheva, and M. S. Yunusov, Russ. J. Bioorg. Chem., 41 (3), 297 (2015).

    Article  CAS  Google Scholar 

  9. Yu. V. Vakhitova, I. P. Tsypysheva, M. Kh. Salimgareeva, A. V. Koval’skaya, A. N. Lobov, U. Sh. Fatkullina, L. F. Zainullina, and M. S. Yunusov, Chem. Nat. Compd., 50, 498 (2014).

    Article  CAS  Google Scholar 

  10. O. Nicolotti, C. Canu Boido, F. Sparatore, and A. Carotti, Farmaco, 57, 469 (2002).

    Article  CAS  Google Scholar 

  11. C. Canu Boido, B. Tasso, V. Boido, and F. Sparatore, Farmaco, 58, 265 (2003).

    Article  Google Scholar 

  12. F. Sparatore, V. Boido, P. Preziosi, E. Miele, and G. De Natale, Farmaco Ed. Sci., 24, 587 (1969).

    CAS  Google Scholar 

  13. S. P. Bondarenko, M. S. Frasinyuk, A. I. Galaev, and V. I. Vinogradova, Chem. Nat. Compd., 48, 234 (2012).

    Article  CAS  Google Scholar 

  14. A. Boido, I. Vazzana, F. Sparatore, M. L. Cenicola, D. Donnoli, and E. Marmo, Farmaco, 46, 775 (1991).

    CAS  PubMed  Google Scholar 

  15. I. Vazzana, R. Budriesi, E. Terranova, P. Ioan, M. P. Ugenti, B. Tasso, A. Chiarini, and F. Sparatore, J. Med. Chem., 50, 334 (2007).

    Article  CAS  Google Scholar 

  16. B. Tasso, R. Budriesi, I. Vazzana, P. Ioan, M. Micucci, F. Novelli, M. Tonelli, A. Sparatore, A. Chiarini, and F. Sparatore, J. Med. Chem., 53, 4668 (2010).

    Article  CAS  Google Scholar 

  17. A. Sparatore, N. Basilico, S. Parapini, S. Romeo, F. Novelli, F. Sparatore, and D. Taramelli, Bioorg. Med. Chem., 13, 5338 (2005).

    Article  CAS  Google Scholar 

  18. M. Casagrande, N. Basilico, S. Parapini, S. Romeo, D. Taramelli, and A. Sparatore, Bioorg. Med. Chem., 16, 6813 (2008).

    Article  CAS  Google Scholar 

  19. B. Tasso, F. Novelli, M. Tonelli, A. Barteselli, N. Basilico, S. Parapini, D. Taramelli, A. Sparatore, and F. Sparatore, ChemMedChem, 10, 1570 (2015).

    Article  CAS  Google Scholar 

  20. B. Tasso, M. Catto, O. Nicolotti, F. Novelli, M. Tonelli, I. Giangreco, L. Pisani, A. Sparatore, V. Boido, A. Carotti, and F. Sparatore, Eur. J. Med. Chem., 46, 2170 (2011).

    Article  CAS  Google Scholar 

  21. M. Tonelli, M. Catto, B. Tasso, F. Novelli, C. Canu, G. Iusco, L. Pisani, A. De Stradis, N. Denora, A. Sparatore, V. Boido, A. Carotti, and F. Sparatore, ChemMedChem, 10, 1040 (2015).

    Article  CAS  Google Scholar 

  22. I. P. Dubovik, M. M. Garazd, V. I. Vinogradova, and V. P. Khilya, Chem. Nat. Compd., 42, 133 (2006).

    Article  CAS  Google Scholar 

  23. I. V. Nagorichna, A. S. Ogorodniichuk, M. M. Garazd, V. I. Vinogradova, and V. P. Khilya, Chem. Nat. Compd., 43, 10 (2007).

    Article  CAS  Google Scholar 

  24. M. V. Veselovskaya, M. M. Garazd, V. I. Vinogradova, and V. P. Khilya, Chem. Nat. Compd., 42, 277 (2006).

    Article  CAS  Google Scholar 

  25. A. V. Yazlovitskii, M. M. Garazd, and V. G. Kartsev, Chem. Nat. Compd., 52, 272 (2016).

    Article  CAS  Google Scholar 

  26. O. I. Muzychuk and M. M. Garazd, Chem. Nat. Compd., 53, 517 (2017).

    Article  CAS  Google Scholar 

  27. S. Yu. Patrikei, Ya. L. Garazd, and M. M. Garazd, Chem. Nat. Compd., 53, 448 (2017).

    Article  CAS  Google Scholar 

  28. Yu. A. Nikitina, A. I. Galaev, Ya. L. Garazd, M. M. Garazd, and V. G. Kartsev, Chem. Nat. Compd., 51, 815 (2015).

    Article  CAS  Google Scholar 

  29. Yu. A. Nikitina, A. I. Galaev, Ya. L. Garazd, M. M. Garazd, and V. G. Kartsev, Chem. Nat. Compd., 52, 52 (2016).

    Article  CAS  Google Scholar 

  30. T. V. Khakimova, O. A. Pukhlyakova, G. A. Shavaleeva, A. A. Fatykhov, E. V. Vasil’eva, and L. V. Spirikhin, Chem. Nat. Compd., 37, 356 (2001).

    Article  CAS  Google Scholar 

  31. A. K. Przybyl and M. Kubicki, J. Mol. Struct., 985, 157 (2011).

    Article  CAS  Google Scholar 

  32. G. W. Anderson and R. Paul, J. Am. Chem. Soc., 80, 4423 (1958).

    Article  CAS  Google Scholar 

  33. R. Paul and G. W. Anderson, J. Am. Chem. Soc., 82, 4596 (1960).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Eximed, 50 Khar’kovskoe Shosse, Kiev, 02160, Ukraine

    R. V. Mironets, Ya. L. Garazd & M. M. Garazd

Authors
  1. R. V. Mironets
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  2. Ya. L. Garazd
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  3. M. M. Garazd
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Correspondence to M. M. Garazd.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 6, November−December, 2019, pp. 958−960.

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Mironets, R.V., Garazd, Y.L. & Garazd, M.M. Synthesis of Conjugates of the Alkaloids Cytisine and Lupinine. Chem Nat Compd 55, 1115–1118 (2019). https://doi.org/10.1007/s10600-019-02907-0

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  • DOI: https://doi.org/10.1007/s10600-019-02907-0

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