Primary and secondary triterpene alcohols were acetylated for the first time using tetraacetylglycoluril (TAGU). Cholesterol, allobetulin, and betulin acetates were obtained in high yields. The acetylation used p-TsOH or TFA in refluxing CHCl3. TFA was found to be an effective acetylation catalyst.
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The work was sponsored by the Ministry of Education and Science of the Russian Federation (Grant No. 05-13108).
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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2019, pp. 412–414.
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Arrous, S., Boudebouz, I., Bakibaev, A. et al. Novel Method for O-Acetylation of Cholesterol, Allobetulin, and Betulin. Chem Nat Compd 55, 482–484 (2019). https://doi.org/10.1007/s10600-019-02720-9
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DOI: https://doi.org/10.1007/s10600-019-02720-9