Two new ent-labdane diterpenes, ent-3α,16-dihydroxylabda-8(17),12(E),14-triene (1) and ent-14(S),15-dihydroxylabda-8(17)-12(E)-dien-18-oic acid (2), were isolated from the roots of Euphorbia yinshanica. Their structures were elucidated on the basis of spectroscopic methods including HR-ESI-MS and 1D and 2D NMR. The cytotoxic activities against five tumor cell lines was also evaluated, but there was no significant activity.
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Acknowledgment
This work was supported by the National Natural Science Foundation of China (NSFC, Grant No. 31500049) and Postdoctoral Science Foundation of China (2014M552077).
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2017, pp. 250–252.
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Zhang, BY., Yin, HX. & Zhang, DJ. Two New ent-Labdane Diterpenes from the Roots of Euphorbia yinshanica . Chem Nat Compd 53, 295–298 (2017). https://doi.org/10.1007/s10600-017-1973-8
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DOI: https://doi.org/10.1007/s10600-017-1973-8