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Covalent Linkage of Gossypol and Dialdehyde Dextran

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Chemistry of Natural Compounds Aims and scope

The structures of the products from addition of gossypol to dialdehyde dextran were studied using 13C NMR and MALDI-TOF mass spectrometry of model compounds and computer modelling. The model reaction was highly stereo- and regiospecific owing to steric hindrance to adding two β-glucose molecules to one gossypol molecule. The main binding sites to the oxidized polysaccharide were determined.

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Acknowledgment

We thank Dr. A. S. Peregudov, Cand. V. A. Polyakov, and Cand. R. Kh. Ziganshin for comprehensive assistance with the work.

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Authors and Affiliations

  1. D. I. Mendeleev Russian Chemical Technology University, Faculty of Oil-and-Gas Chemistry and Polymers, 9 Miusskaya Sq., Moscow, 125047, Russia

    V. A. Dyatlov, I. S. Kruppa & V. V. Kireev

  2. All-Russian Research Institute of Aviation Materials, 17 Radio St., Moscow, 105005, Russia

    T. A. Grebeneva

  3. State Research Institute of Organoelement Compound Chemistry and Technology, 38 Entuziastov Sh., Moscow, 105118, Russia

    I. B. Sokol′skaya

Authors
  1. V. A. Dyatlov
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  2. I. S. Kruppa
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  3. T. A. Grebeneva
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  4. V. V. Kireev
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  5. I. B. Sokol′skaya
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Correspondence to V. A. Dyatlov.

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Dyatlov, V.A., Kruppa, I.S., Grebeneva, T.A. et al. Covalent Linkage of Gossypol and Dialdehyde Dextran. Chem Nat Compd 52, 628–633 (2016). https://doi.org/10.1007/s10600-016-1726-0

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  • DOI: https://doi.org/10.1007/s10600-016-1726-0

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