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Natural Pseudoguaianolides Prepared from Damsin

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Chemistry of Natural Compounds Aims and scope

Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3α-hydroxydamsin (4), 3α-acetoxydamsin (5), and 11β,13-dihydrodamsin (8) were prepared by regio- and stereo-selective synthetic modifications.

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Acknowledgment

The authors are grateful to the Swedish International Development Agency (SIDA) for support of this study, which is part of the Project “Research on Plant Biodiversity” developed between the University of San Andres (UMSA La Paz – Bolivia) and Lund University (Sweden).

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Authors and Affiliations

  1. Center for Analysis and Synthesis, Lund University, SE-221 00, Getingevagen 60/Solvegatan 39, Lund, Sweden

    R. Villagomez & O. Sterner

  2. Laboratorio de Bioorganica, Instituto de Investigaciones Quimicas, Universidad Mayor de San Andres CP 303, Calle 27 Cota Cota, La Paz, Bolivia

    R. Villagomez, M. Quiroz, A. Tito & G. R. Almanza

Authors
  1. R. Villagomez
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  2. M. Quiroz
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  3. A. Tito
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  4. O. Sterner
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  5. G. R. Almanza
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Corresponding author

Correspondence to G. R. Almanza.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2015, pp. 582–586.

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Villagomez, R., Quiroz, M., Tito, A. et al. Natural Pseudoguaianolides Prepared from Damsin. Chem Nat Compd 51, 675–680 (2015). https://doi.org/10.1007/s10600-015-1382-9

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  • DOI: https://doi.org/10.1007/s10600-015-1382-9

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