Two new xanthones, 4,5-dihydroxy-3-(2-hydroxyethyl)-1-methoxy-8-methoxycarbonylxanthone (1) and 1,8-dihydroxy-4-(2-hydroxyethyl)-3-methoxyxanthone (2), and seven known xanthones (3–9) were isolated from the fermentation products of a Phomopsis species fungus. Compounds 1, 2, and 7 were tested for their cytotoxicity against five human tumor cell lines. Compound 1 showed cytotoxicity against A549 and PC3 cells with IC50 values of 2.6 and 2.4 μM, respectively. The other compounds also showed moderate cytotoxicity for some tested cell lines with IC50 values between 5.2–9.2 μM.
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Acknowledgment
This research was supported by the National Natural Science Foundation of China (No. 21462051), the Excellent Scientific and Technological Team of Yunnan High School (2010CI08), the Yunnan University of Nationalities, Green Chemistry and Functional Materials Research for Provincial Innovation Team (2011HC008), and start-up funds of Yunnan University of Nationalities.
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2015, pp. 401–403.
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Yuan, L., Huang, W., Du, G. et al. Isolation of Xanthones from the Fermentation Products of the Endophytic Fungus of Phomopsis amygdali . Chem Nat Compd 51, 460–463 (2015). https://doi.org/10.1007/s10600-015-1315-7
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DOI: https://doi.org/10.1007/s10600-015-1315-7