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Anti-Osteoporotic Components of Rubus chingii

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Chemistry of Natural Compounds Aims and scope

Phytochemical studies of Rubus chingii Hu afforded a new chromone (1), identified as rubusin B, along with six known compounds, kaempferol (2), rubusin A (3), quercetin (4), β-sitosterol (5), oleanolic acid (6), and liballinol (7). All the chemical structures were identified using 1D and 2D NMR data and MS data. It was found that compounds 1–4 displayed anti-osteoporotic activities to different degrees, quercetin and kaempferol significantly increased alkaline phosphatase (ALP) activity and can stimulate osteoblastic activity, and rubusin A and B strongly inhibit osteoclastic cell and bone resorption even at a concentration of 0.01 ppm.

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Acknowledgment

This research was supported by the National Natural Science Foundation (No. 91271974), Science Foundation of Zhejiang Province (LY13H060005), and General Foundation of Zhejiang Province (2013KYA201).

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Authors and Affiliations

  1. Department of Orthopaedics, Shaoxing People’s Hospital, 568 Zhongxing North Road, 312000, Shaoxing, P. R. China

    Wen-Qing Liang, Guo-Jian Xu, Dong Weng & Yu Qian

  2. Osteology Department of PLA 306 Hospital, 9 Anxiang North Road, 100101, Beijing, P. R. China

    Bo Gao

  3. Burns Department of Changhai Hospital, Second Military Medical University, 168 Changhai Road, 200433, Shanghai, P. R. China

    Xing-Feng Zheng

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  1. Wen-Qing Liang
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  2. Guo-Jian Xu
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  3. Dong Weng
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  4. Bo Gao
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  5. Xing-Feng Zheng
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  6. Yu Qian
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Correspondence to Yu Qian.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2015, pp. 43–45.

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Liang, WQ., Xu, GJ., Weng, D. et al. Anti-Osteoporotic Components of Rubus chingii . Chem Nat Compd 51, 47–49 (2015). https://doi.org/10.1007/s10600-015-1200-4

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  • DOI: https://doi.org/10.1007/s10600-015-1200-4

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