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Two New Diketopiperazines from ARUM Palaestinum

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Chemistry of Natural Compounds Aims and scope

The phytochemical investigation of the water extract of Arum palaestinum led to the isolation of three compounds identified as isoorientin (luteolin 6-C-β-D-glucopyranoside), vitexin (apigenin 8-C-β-Dglucopyranoside), and vicenin II (apigenin 6,8-di-C-β-D-glucopyranoside) as well as two new diketopiperazines (DKP), namely 3-hydroxypiperazine-2,5-dione (1) and piperazine-2,5-dione (2). The chemical structures of the isolated compounds were established by spectroscopic methods including IR, MS, and NMR. The new diketopiperazine (1) exhibited mild cytotoxic activity against human multidrug-resistant cell line MES-SA/DX5 with ED50 3.44 μM.

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Acknowledgment

This study was supported in part by a 2012 Kookmin University Research Grant and a Grant (S211313L010110) from Forest Science & Technology Projects, Forest Service. Republic of Korea.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Jazan University, 2097, -Jazan, Saudi Arabia

    Samy K. El-Desouky

  2. Marine Chemistry Department, Faculty of Marine Sciences, King Abdulaziz University, P. O. Box 80207, Jeddah, 21589, Saudi Arabia

    Usama W. Hawas

  3. Phytochemistry and Plant Systematic Department, National Research Centre, Dokki, -12311, Cairo, Egypt

    Samy K. El-Desouky & Usama W. Hawas

  4. Forest Products Department, College of Forest Science, Kookmin University, 861-1 Chongnung-dong, Songbuk-gu, Seoul, 136-702, Korea

    Young-Kyoon Kim

Authors
  1. Samy K. El-Desouky
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  2. Usama W. Hawas
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  3. Young-Kyoon Kim
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Corresponding author

Correspondence to Samy K. El-Desouky.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2014, pp. 936–938.

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El-Desouky, S.K., Hawas, U.W. & Kim, YK. Two New Diketopiperazines from ARUM Palaestinum . Chem Nat Compd 50, 1075–1078 (2014). https://doi.org/10.1007/s10600-014-1162-y

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  • DOI: https://doi.org/10.1007/s10600-014-1162-y

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