A new flavolignan, isohydnocarpin A (1), together with three known flavolignans, isohydnocarpin (2), hydnocarpin B (3), and hydnocarpin D (4), was isolated from the leaves of Nelumbo nicifera. The structure of the new compound was determined based on spectroscopic methods including 1D and 2D NMR and MS spectrometry. The stereochemistry was determined by NOESY experiments.
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H. Y. Lin, Y. H. Kuo, Y. L. Lin, and W. Chiang, J. Agric. Food Chem., 57, 6623 (2009).
C. F. Huang, Y. W. Chen, C. Y. Yang, H. Y. Lin, T. D. Way, W. Chiang, and S. H. Liu, J. Agric. Food Chem., 59, 1087 (2011).
Y. Ono, E. Hattori, Y. Fukaya, S. Imai, and Y. Ohizumi, J. Ethnopharmacol., 106, 238 (2006).
A. Itoh, T. Saitoh, K. Tani, M. Uchigaki, Y. Sugimoto, J. Yamada, H. Nakajima, H. Ohshiro, S. Sun, and T. Tanahashi, Chem. Pharm. Bull., 59, 947 (2001).
Z. Zheng, M. Wang, D. Wang, W. Duan, X. Wang, and C. Zheng, J. Chromatogr. B, 878, 1647 (2010).
J. H. Ahn, E. S. Kim, C. Lee, S. Kim, S. H. Cho, B. Y. Hwang, and M. K. Lee, Bioorg. Med. Chem. Lett., 23, 3604 (2013).
M. R. Parthasarathy, K. R. Ranganathan, and D. K. Sharma, Phytochemistry, 18, 506 (1979).
N. C. Kim, T. N. Graf, C. M. Sparacino, M. C. Wani, and M. E. Wall, Org. Biomol. Chem., 1, 1684 (2003).
L. Pan, Y. C. Chin, H. B. Chai, T. N. Ninh, D. D. Soejarto, and A. D. Kinghorn, Bioorg. Med. Chem., 17, 2219 (2009).
N. R. Guz and F. R. Stermitz, J. Nat. Prod., 63, 1140 (2000).
Acknowledgment
This study was supported by a research grant from the National Institute of Biological Resource (NIBR) through the Ministry of the Environment, and the Medical Research Center Program (2010-0029480) through the National Research Foundation of Korea.
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2014, pp. 867–868.
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Ahn, J.H., Kim, S.B., Kim, E.S. et al. A New Flavolignan from Nelumbo nucifera Leaves. Chem Nat Compd 50, 998–1000 (2014). https://doi.org/10.1007/s10600-014-1145-z
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DOI: https://doi.org/10.1007/s10600-014-1145-z