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A 1,3-dipolar cycloaddition of azomethine ylides to imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazine oxindolylidene derivatives in the synthesis of novel spirooxindole derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

The stereochemistry of the 1,3-dipolar cycloaddition reaction of azomethine ylides to oxindolylidene derivatives of imidazo[4,5-e]-thiazolo[2,3-c][1,2,4]triazine leading to a mixture of diastereomeric derivatives of dispiro[imidazothiazolotriazine-7,3'-pyrrolidine-4',3''-oxindole] was studied. It was shown that the corresponding syn- and anti-stereoisomers can be isolated individually by fractional crystallization from reaction mixtures without the use of chromatographic methods.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia

    Alexei N. Izmest’ev, Angelina N. Kravchenko & Galina A. Gazieva

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  1. Alexei N. Izmest’ev
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  2. Angelina N. Kravchenko
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  3. Galina A. Gazieva
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Correspondence to Alexei N. Izmest’ev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2023, 59(8), 594–603

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Izmest’ev, A.N., Kravchenko, A.N. & Gazieva, G.A. A 1,3-dipolar cycloaddition of azomethine ylides to imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazine oxindolylidene derivatives in the synthesis of novel spirooxindole derivatives. Chem Heterocycl Comp 59, 594–603 (2023). https://doi.org/10.1007/s10593-023-03238-3

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