A novel series of dispiro(indolinonepyrrolidineiminothiazolidinones) were synthesized by 1,3-dipolar cycloaddition of 5-arylmethylidene-2-iminothiazolidin-4-ones and azomethine ylides generated from N-alkylamino acids and isatin derivatives. A number of iminothiazolidinones and dispiro compounds were tested for antiproliferative activity. Seven compounds showed moderate antiproliferative activity at micromolar concentrations against cancer cell lines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2023, 59(4/5), 309–316
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Izmest’ev, A.N., Streltsov, A.A., Kravchenko, A.N. et al. 5-Arylmethylidene-2-iminothiazolidin-4-ones in the synthesis of novel dispiro-fused oxindolepyrrolidineiminothiazolidinones. Chem Heterocycl Comp 59, 309–316 (2023). https://doi.org/10.1007/s10593-023-03198-8
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DOI: https://doi.org/10.1007/s10593-023-03198-8