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Synthetic transformations of sesquiterpene lactones. Controllable synthesis of 11,13-dihydroisoalantolactone azides and 13-(1,2,3-triazolyl)eudesmanolides based on sesquiterpene lactones

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Chemistry of Heterocyclic Compounds Aims and scope

Modification of eudesmane-type lactones isoalantolactone and 4,15-epoxyisoalantolactone was carried out at the active methylene group. The reaction of isoalantolactone with hydrazoic acid, which was formed in situ from sodium azide and acetic acid in the presence of triethylamine in toluene or DMF, proceeds in a controllable manner and, depending on the nature of the solvent and reaction conditions, leads to (11R)-13-azido-11,13-dihydroisoalantolactone, the spirocyclic compound (11R)-aziridino[11,13]dihydroisoalantolactone, and the product of the selective opening of the aziridine ring with the azide anion (11S)-11-amino-13-azido-11,13-dihydroisoalantolactone. The reaction of 4,15-epoxyisoalantolactone with hydrazoic acid proceeds similarly to form the corresponding 13-azido-, (11R)-aziridino[11,13]-, or (11S)-11-amino-13-azido-4,15-epoxy-11,13-dihydroisoalantolactones. The regioselective synthesis of libraries of (11R)-13-(1H-1,2,3-triazolyl)-11,13-dihydroisoalantolactones and (11S)-11-amino-13-(1H-1,2,3-triazolyl)-11,13-dihydroisoalantolactones containing various aryl or hetaryl substituents at the C-4 position of the triazole ring was carried out by the CuAAC reaction of 13-azido-substituted 11,13-dihydroisoalantolactones with terminal acetylenes.

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk, 630090, Russia

    Sergey S. Patrushev, Tatyana V. Rybalova & Elvira E. Shults

  2. Novosibirsk State University, 1 Pirogova St., Novosibirsk, 630090, Russia

    Sergey S. Patrushev

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  1. Sergey S. Patrushev
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  2. Tatyana V. Rybalova
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  3. Elvira E. Shults
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Correspondence to Elvira E. Shults.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(11), 1116–1129

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Patrushev, S.S., Rybalova, T.V. & Shults, E.E. Synthetic transformations of sesquiterpene lactones. Controllable synthesis of 11,13-dihydroisoalantolactone azides and 13-(1,2,3-triazolyl)eudesmanolides based on sesquiterpene lactones. Chem Heterocycl Comp 57, 1116–1129 (2021). https://doi.org/10.1007/s10593-021-03030-1

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