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Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

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Chemistry of Heterocyclic Compounds Aims and scope

A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.

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The authors thank University of Hyderabad for NMR spectroscopic analyses. Karuna Raman Paidi, Murali Krishna Kolli, and Venkata Ramana Pedakotla acknowledge Department of chemistry, Sri Krishnadevaraya University for laboratory facilities.

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Authors and Affiliations

  1. Sri Krishnadevaraya University, Ananthapur, Andhra Pradesh, 515003, India

    Karuna Raman Paidi, Murali Krishna Kolli & Venkata Ramana Pedakotla

  2. Vignan’s Foundation for Science, Technology and Research (Deemed to be University), Rd., Vadlamudi, Guntur–Tenali, Andhra Pradesh, 522213, India

    Eeda Koti Reddy

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  1. Karuna Raman Paidi
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  3. Eeda Koti Reddy
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Correspondence to Venkata Ramana Pedakotla.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(3), 371–376

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Paidi, K.R., Kolli, M.K., Reddy, E.K. et al. Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes. Chem Heterocycl Comp 56, 371–376 (2020). https://doi.org/10.1007/s10593-020-02669-6

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