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Effective method for the synthesis of azolo[1,5-a]pyrimidin-7-amines

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Chemistry of Heterocyclic Compounds Aims and scope

Condensation of aminoazoles with (2E)-(3-morpholin-4-yl)acrylonitrile and 3,3-diethoxypropionitrile was used to synthesize a series of azolo[1,5-a]pyrimidin-7-amines. It was established that the reactions with certain aminotriazoles gave mixtures of regioisomers: azolo[1,5-а]pyrimidin-7-amines and azolo[4,3-а]pyrimidin-5-amines.

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The results were obtained within the framework of State Assignment of the Ministry of Education and Science of the Russian Federation (No. 4.6351.2017/8.9).

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Authors and Affiliations

  1. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg, 620990, Russia

    Denis A. Gazizov, Evgeny B. Gorbunov, Evgeny N. Ulomskiy, Gennady L. Rusinov & Vladimir L. Rusinov

  2. Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg, 620002, Russia

    Victor V. Fedotov, Evgeny N. Ulomskiy, Oleg S. Yeltsov, Gennady L. Rusinov & Vladimir L. Rusinov

Authors
  1. Denis A. Gazizov
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  2. Victor V. Fedotov
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  3. Evgeny B. Gorbunov
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  4. Evgeny N. Ulomskiy
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  5. Oleg S. Yeltsov
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  6. Gennady L. Rusinov
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  7. Vladimir L. Rusinov
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Corresponding author

Correspondence to Denis A. Gazizov.

Additional information

Supplementary information file containing 1Н, 13С NMR and 1H–13C HSQC, 1H–13С HMBC spectra of compounds 3a–h, 5a is available at the journal website at http://link.springer.com/journal/10593.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(6), 573–577

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Gazizov, D.A., Fedotov, V.V., Gorbunov, E.B. et al. Effective method for the synthesis of azolo[1,5-a]pyrimidin-7-amines. Chem Heterocycl Comp 55, 573–577 (2019). https://doi.org/10.1007/s10593-019-02498-2

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  • DOI: https://doi.org/10.1007/s10593-019-02498-2

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