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5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction

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Chemistry of Heterocyclic Compounds Aims and scope

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)-urea in the presence of FeCl3·6H2O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylates was obtained.

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This publication was supported by the Ministry of Education and Science of Ukraine (project 0118U003610) and by the Ministry of Education and Science of the Russian Federation (project 4.1154.2017/4.6).

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Authors and Affiliations

  1. Ivan Franko National University of Lviv, 6 Kyryla i Mefodiya St., Lviv, 79005, Ukraine

    Andriy R. Vakhula, Yuriy I. Horak, Roman Z. Lytvyn, Alexandra I. Lesyuk & Mykola D. Obushak

  2. Institute of Low Temperature and Structure Research, 50-422, Wroclaw, Poland

    Vasyl Kinzhybalo

  3. RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russia

    Fedor I. Zubkov

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  1. Andriy R. Vakhula
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  2. Yuriy I. Horak
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  3. Roman Z. Lytvyn
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Correspondence to Mykola D. Obushak.

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Published in Khimiya Geterotsiklicheskikh Soedinenii,2018, 54(5), 545–549

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Vakhula, A.R., Horak, Y.I., Lytvyn, R.Z. et al. 5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction. Chem Heterocycl Comp 54, 545–549 (2018). https://doi.org/10.1007/s10593-018-2301-3

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