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Synthesis of spiro[imidazo[2,1-b][1,3]thiazole-6,3'-pyrrolidine] derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

6-Arylidene-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5(6Н)-ones reacted with N-alkylazomethine ylides by [2+3] cycloaddition mechanism, resulting in the formation of diastereomeric spiro[imidazo[2,1-b][1,3]thiazole-6,3'-pyrrolidin]-5(6Н)-ones, which were separated by column chromatography.

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Authors and Affiliations

  1. Lesya Ukrainka East European National University, 13 Voli Ave., Lutsk, 43025, Ukraine

    Lesya M. Saliyeva & Nataliia Yu. Slyvka

  2. Ivano-Frankivsk National Medical University, 2 Galytska St., Ivano-Frankivsk, 78016, Ukraine

    Dmitro A. Mel’nyk

  3. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02094, Ukraine

    Eduard B. Rusanov, Ruslan I. Vas’kevich & Mikhailo V. Vovk

Authors
  1. Lesya M. Saliyeva
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  2. Nataliia Yu. Slyvka
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  3. Dmitro A. Mel’nyk
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  4. Eduard B. Rusanov
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  5. Ruslan I. Vas’kevich
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  6. Mikhailo V. Vovk
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Correspondence to Lesya M. Saliyeva.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(2), 130–137

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Saliyeva, L.M., Slyvka, N.Y., Mel’nyk, D.A. et al. Synthesis of spiro[imidazo[2,1-b][1,3]thiazole-6,3'-pyrrolidine] derivatives. Chem Heterocycl Comp 54, 130–137 (2018). https://doi.org/10.1007/s10593-018-2244-8

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  • DOI: https://doi.org/10.1007/s10593-018-2244-8

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