A new methodology for the synthesis of piperazine derivatives is analyzed, starting from 1,4-diazabicyclo[2.2.2]octane as the source of piperazine ring and quaternary ammonium salts obtained from 1,4-diazabicyclo[2.2.2]octane as synthetic intermediates. This microreview summarizes literature data published over the last 15 years.
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Bugaenko, D.I. 1,4-Diazabicyclo[2.2.2]octane in the synthesis of piperazine derivatives (microreview). Chem Heterocycl Comp 53, 1277–1279 (2017). https://doi.org/10.1007/s10593-018-2205-2
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DOI: https://doi.org/10.1007/s10593-018-2205-2