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Synthesis of 5-(pyrazol-1-yl)-1,2,3-thiadiazoles

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Chemistry of Heterocyclic Compounds Aims and scope

A method is proposed for the synthesis of ethyl 5-(3-aryl-4-formyl-1H-pyrazol-1-yl)-1,2,3-thiadiazole-4-carboxylates by a reaction of acetophenone (4-ethoxycarbonyl-1,2,3-thiadiazol-5-yl)hydrazones with a Vilsmeier–Haack complex. The obtained heterocyclic assemblies provide interesting substrates for further modification and study of biological activity.

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This work was performed with financial support from the Russian Science Foundation (grant 16-16-04022).

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Authors and Affiliations

  1. Ural Federal University named after the First President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg, 620002, Russia

    Olga A. Vysokova, Tatiana A. Kalinina, Marina A. Tokareva, Tatiana A. Pospelova, Tatiana V. Glukhareva & Yuri Yu. Morzherin

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  1. Olga A. Vysokova
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  2. Tatiana A. Kalinina
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  3. Marina A. Tokareva
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  4. Tatiana A. Pospelova
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  5. Tatiana V. Glukhareva
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  6. Yuri Yu. Morzherin
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Corresponding author

Correspondence to Tatiana V. Glukhareva.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(2), 236–238

Yuri Yu. Morzherin is deceased.

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Vysokova, O.A., Kalinina, T.A., Tokareva, M.A. et al. Synthesis of 5-(pyrazol-1-yl)-1,2,3-thiadiazoles. Chem Heterocycl Comp 53, 236–238 (2017). https://doi.org/10.1007/s10593-017-2045-5

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  • DOI: https://doi.org/10.1007/s10593-017-2045-5

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