We propose a single-step procedure for the synthesis of 8-oxo-10-sulfanylpyrido[4',3':4,5]thieno[3,2-d]pyrimidines, annulated with pyran, cyclohexane, or cyclopentane rings. The alkylation of these compounds in aqueous DMF solution of KOH at room temperature was shown to proceed regioselectively and led to the formation of S-substituted products. Amino- and alkoxy-substituted derivatives of tetracyclic thieno[3,2-d]pyrimidines were synthesized. The antimicrobial activity of the obtained compounds was studied on Grampositive staphylococci and Gram-negative rods.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(5), 337–345
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Paronikyan, E.G., Dashyan, S.S., Minasyan, N.S. et al. Synthesis of 10-alkylsulfanyl-substituted pyrido-[4',3':4,5]thieno[3,2-d]pyrimidines annulated with pyran, cyclohexane, and cyclopentane rings. Chem Heterocycl Comp 52, 337–345 (2016). https://doi.org/10.1007/s10593-016-1887-6
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DOI: https://doi.org/10.1007/s10593-016-1887-6